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dc.contributor.authorMCMANUS, ROSSen
dc.contributor.authorLYNCH, MARINAen
dc.contributor.authorMILLS, KINGSTONen
dc.date.accessioned2013-10-10T10:18:22Z
dc.date.available2013-10-10T10:18:22Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationMcManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, 1, 2014, 109 121en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/67483
dc.descriptionPUBLISHEDen
dc.description.abstractAlzheimer?s disease (AD) is a progressive neurodegenerative disease characterized by deposits of amyloid-? and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease; however, it has not been established if these are a consequence of ongoing neurodegeneration or whether inflammation itself contributes to disease pathogenesis. Recent studies suggest that exposure to infection can accelerate cognitive decline in AD patients, and pathogens have been detected in the AD brain. However, the influence of infection on neuroinflammation and pathology remains poorly understood. In this study, we examined the effect of a peripheral infection on AD pathology in APP/PS1 mice. We found that, 8 weeks after infection with the Gram negative respiratory pathogen Bordetella pertussis, there was significant infiltration of IFN?- and IL-17-producing T cells and NKT cells in older APP/PS1 mice. This was accompanied by increased glial activation and amyloid ? deposition. The data suggest that infection is a critical factor in the progression of AD, emphasising the importance of early diagnosis and treatment of infections in elderly individuals.en
dc.description.sponsorshipThis work was supported by grants from Science Foundation Ireland, the Health Research Board, and an Innovation Bursary.en
dc.format.extent109-121en
dc.language.isoenen
dc.relation.ispartofseriesNeurobiol Agingen
dc.relation.ispartofseries35en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectAlzheimer?s disease, infection, T cell, microglia, amyloid ?, neuroinflammationen
dc.subject.lcshAlzheimer?s disease, infection, T cell, microglia, amyloid ?, neuroinflammationen
dc.titleRespiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lynchmaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/millsken
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rmcmanusen
dc.identifier.rssinternalid88051en
dc.identifier.doihttp://dx.doi.org/10.1016/j.neurobiolaging.2013.07.025en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeNeuroscienceen


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