| dc.contributor.author | Williams, David | en |
| dc.contributor.author | Gunnlaugsson, Thorfinnur | en |
| dc.contributor.author | Cloonan, Suzanne | en |
| dc.date.accessioned | 2012-06-28T11:49:33Z | |
| dc.date.available | 2012-06-28T11:49:33Z | |
| dc.date.issued | 2011 | en |
| dc.date.submitted | 2011 | en |
| dc.identifier.citation | Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, 686 - 688 | en |
| dc.identifier.other | Y | en |
| dc.identifier.uri | http://hdl.handle.net/2262/64079 | |
| dc.description | PUBLISHED | en |
| dc.description.abstract | The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation. | en |
| dc.description.sponsorship | We thank Science Foundation Ireland (SFI RFP 2009), HEA PRTLI Cycle 4, The Irish Research Council for Science, Engineering and Technology (IRCSET Postgraduate Studentship to RPBE) and TCD (Postgraduate Award to ME) for financial support. | en |
| dc.format.extent | 686 | en |
| dc.format.extent | 688 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Chemical Communications | en |
| dc.relation.ispartofseries | 47 | en |
| dc.rights | Y | en |
| dc.subject | quaternarized pdppz derivative 1 | en |
| dc.subject | dppz derivative | en |
| dc.subject | cellular death | en |
| dc.subject | apoptosis | en |
| dc.title | Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation | en |
| dc.type | Journal Article | en |
| dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
| dc.contributor.sponsor | Higher Education Authority (HEA) | en |
| dc.contributor.sponsor | Irish Research Council for Science and Engineering Technology (IRCSET) | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/dwillims | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/gunnlaut | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/cloonas | en |
| dc.identifier.rssinternalid | 69250 | en |
| dc.identifier.doi | http://dx.doi.org/10.1039/C0CC04303F | en |
| dc.contributor.sponsorGrantNumber | SFI RFP 2009 | en |
| dc.subject.TCDTheme | Cancer | en |
