Browsing Histopathology & Morbid Anatomy by Title
Now showing items 75-94 of 105
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Next-generation sequencing reveals deep intronic cryptic ABCC8 and HADH splicing founder mutations causing hyperinsulinism by pseudoexon activation.
(2013)Next-generation sequencing (NGS) enables analysis of the human genome on a scale previously unachievable by Sanger sequencing. Exome sequencing of the coding regions and conserved splice sites has been very successful in ... -
Non-coding RNA expression in cancer stem cell progenies derived from tumours +/-BRAF V600E mutation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Cancer has placed a huge burden on the global health system and rising rates in particular cancer types such as lung cancer and melanoma due to smoking and increased UV ray exposure respectively has highlighted the need ... -
Non-invasive and non-destructive measurements of confluence in cultured adherent cell lines
(2015)Many protocols used for measuring the growth of adherent monolayer cells in vitro are invasive, destructive and do not allow for the continued, undisturbed growth of cells within flasks. Protocols often use indirect methods ... -
Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review.
(WB Saunders, 2007)Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ... -
Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
(Springer, 2006)Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ... -
Platinum and taxane chemoresistance mechanisms in ovarian cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Ovarian cancer is the leading cause of death from a gynaecological malignancy, typically presenting at late stage due to difficult diagnosis and lack of suitable screening tools. The standard treatment of combination ... -
Post-transcriptional Dysregulation by microRNAs is implicated in the Pathogenesis of Gastrointestinal Stromal Tumour [GIST]
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)In a cohort of 73 GISTs including adult mutant, adult wild-type and paediatric cases miRNA expression was examined using TaqMan® Low Density Arrays (TLDAs), allowing the profiling of 667 miRNAs in a set of two (pool A and ... -
Post-Transcriptional Dysregulation by miRNAs Is Implicated in the Pathogenesis of Gastrointestinal Stromal Tumor [GIST]
(2013)In contrast to adult mutant gastrointestinal stromal tumors [GISTs], pediatric/wild-type GISTs remain poorly understood overall, given their lack of oncogenic activating tyrosine kinase mutations. These GISTs, with a ... -
Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act.
(2014)OBJECTIVES: The incidence of human papillomavirus (HPV)-associated anal cancer is increasing. Men who have sex with men (MSM), particularly those coinfected with HIV, are disproportionately affected. Documenting the ... -
Prognostic markers in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2000)Prognosis in thyroid carcinoma is usually assessed on the basis of criteria, which include patient age and histological type, grade and stage of tumour. It is well recognised, however, that while occasional tumours with ... -
Regulation of cancer stem cell differentiation by genes and microRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Since the discovery of a stem cell phenotype in cancer, specific tumour cells with this phenotype, often called cancer stem cells (CSCs), are now widely accepted as the progenitors of oncogenesis, proliferation, treatment ... -
Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients.
(2009)Background: Tumours with high proportions of differentiated cells are considered to be of a lower grade to those containing high proportions of undifferentiated cells. This property may be linked to the differentiation ... -
Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein
(2012)The IGROVCDDP cisplatin-resistant ovarian cancer cell line is also resistant to paclitaxel and models the resistance phenotype of relapsed ovarian cancer patients after first-line platinum/taxane chemotherapy. A TaqMan ... -
Similar chromosomal changes in cisplatin-resistant and oxaliplatin-resistant sublines of the H69 SCLC cell line are not associated with platinum resistance.
(2006)Small cell lung cancer (SCLC) initially responds well to DNA damaging drugs such as cisplatin, however this is transitory as resistance normally develops. To investigate whether changes in chromosomal copy number caused ... -
SPINK1 protein expression and prostate cancer progression.
(2014)PURPOSE: SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis in many cancers. The objective of this study was to characterize the association between SPINK1 overexpression and ... -
A systematic review of genes involved in the inverse resistance relationship between cisplatin and paclitaxel chemotherapy: Role of BRCA1.
(Bentham Science, 2009)A systematic review of cell models of acquired drug resistance not involving genetic manipulation showed that 80% of cell models had an inverse resistance relationship between cisplatin and paclitaxel[1]. Here we ...