Post-transcriptional Dysregulation by microRNAs is implicated in the Pathogenesis of Gastrointestinal Stromal Tumour [GIST]
Citation:Lorna Catherine-Noelle Kelly, 'Post-transcriptional Dysregulation by microRNAs is implicated in the Pathogenesis of Gastrointestinal Stromal Tumour [GIST]', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013, pp 355
In a cohort of 73 GISTs including adult mutant, adult wild-type and paediatric cases miRNA expression was examined using TaqMan® Low Density Arrays (TLDAs), allowing the profiling of 667 miRNAs in a set of two (pool A and B) 384well cards. Individual TaqMan® miRNA assays used to validate the arrays cards showed good concordance with array results. Unsupervised hierarchical clustering splits the cases into two large clusters A and B, which are further subdivided into clusters B1 and B2. Adult mutant cases are located in clusters A and B1 and paediatric cases in cluster B2.
Author: Kelly, Lorna Catherine-Noelle
Publisher:Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy
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Type of material:thesis
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