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  • Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum. 

    LAWLESS, MATTHEW; KELLEHER, DERMOT; SHEILS, ORLA; O'FARRELLY, CLIONA (1994)
    A 12 amino acid sequence from the adenovirus 12 E1B protein is homologous at the protein level with a similar 12-mer derived from the wheat protein A-gliadin. It has been suggested that exposure to Ad 12 could sensitise ...
  • Tyrosine phosphorylation in the human duodenum. 

    KELLEHER, DERMOT P; SHEILS, ORLA (BMJ, 1995)
    Many growth factor receptors including the epidermal growth factor receptor function through tyrosine kinase activity. The aim of this study was to examine the constitutive level of tyrosine phosphorylation in the normal ...
  • Prognostic markers in thyroid neoplasia 

    Sheils, Orla (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2000)
    Prognosis in thyroid carcinoma is usually assessed on the basis of criteria, which include patient age and histological type, grade and stage of tumour. It is well recognised, however, that while occasional tumours with ...
  • C-ABL in human cancer: an investigation of its role in apoptosis inhibition, differentiation and angiogenesis 

    Russell, Jennifer M. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)
    Research over the past number of decades has significantly advanced our understanding of the cell signalling effects that mediate a diverse array of cellular activities including cell proliferation, homeostasis and ...
  • Molecular analysis of Human Herpes Virus 8 and associated lesions 

    Silva, Ivan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)
    This thesis looks at the bio-pathways of HHV8 through the transformation of endothelial cell lines. This was performed in two separate but mutually contributing experiments. First, endothelial cell lines were infected using ...
  • Molecular markers in cervical cancer 

    Murphy, Niamh (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)
    Despite the introduction of the Papanicolaou (Pap) test carcinoma of the cervix remains one of the most common malignancies amongst women worldwide. It is hoped that the use of HPV testing and molecular biomarkers in ...
  • Molecular characterisation of a new variant of inflammatory bowel disease in children with autism 

    Martin, Cara (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)
    A new variant of inflammatory bowel disease, provisionally termed "autistic enterocolitis" has been described in a cohort of children with autistic spectrum disorders. The intestinal pathology includes ileo-colonic ...
  • Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum. 

    KELLEHER, DERMOT P; MURPHY, ANNE; SHEILS, ORLA (Hindawi, 2005)
    Studies of tyrosine phosphorylation in the human duodenum have indicated that proliferating cells in the middle portion of the duodenal crypt were devoid of this feature, suggesting that tyrosine kinase activation is not ...
  • Genome wide investigation of papillary thyroid carcinoma 

    Finn, Stephen (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)
    In recent years, there has been a technological explosion in the fields of molecular pathology and molecular oncology. The genome, transcriptome and increasingly the proteome of diverse tumours can now be analysed in minute ...
  • Molecular algorithms in thyroid neoplasia 

    Smyth, Paul (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)
    Papillary thyroid carcinoma is the most comm on thyroid malignancy, with an incidence of <100 cases per year in Ireland and 16,000 cases per year in the U.S. Incidence is increasing with a global estimate of half a million ...
  • Investigation of oral and oropharyngeal squamous cell carcinoma in young adults 

    O'Regan, Esther (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2006)
    While oral and pharyngeal squamous cell carcinoma is classically a disease of older male smokers, this tumour type can occur in young patients with minimal or no exposure to the traditional risk factors. The prognosis ...
  • Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells 

    STORDAL, BRITTA KRISTINA (Springer, 2006)
    Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...
  • Similar chromosomal changes in cisplatin-resistant and oxaliplatin-resistant sublines of the H69 SCLC cell line are not associated with platinum resistance. 

    STORDAL, BRITTA KRISTINA (2006)
    Small cell lung cancer (SCLC) initially responds well to DNA damaging drugs such as cisplatin, however this is transitory as resistance normally develops. To investigate whether changes in chromosomal copy number caused ...
  • Molecular signatures in papillary thyroid carcinoma 

    Cahill, Susanne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2007)
    Papillary thyroid carcinomas (PTC) are the most frequently occurring type of thyroid malignancy (85%-90%). PTC affects females more frequently than males, with a ratio of 3:1 and can be present in any age group, the mean ...
  • Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review. 

    STORDAL, BRITTA KRISTINA (WB Saunders, 2007)
    Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...
  • Understanding cisplatin resistance using cellular models. 

    STORDAL, BRITTA KRISTINA (John Wiley, 2007)
    Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of ...
  • A systematic review of platinum and taxane resitance from bench to clinic: An inverse relationship. 

    STORDAL, BRITTA KRISTINA (WB Saunders, 2007)
    We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for 1) cell models of acquired drug ...
  • Molecular signatures of prostate cancer 

    Murphy, Amanda (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2008)
    Prostate cancer is the second most common cancer in Irish men and the second most common cause of cancer-related deaths. In the United States, there are approximately 234,000 new cases diagnosed every year and 27,350 deaths. ...
  • A 39kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome. 

    STORDAL, BRITTA KRISTINA (John Wiley, 2008)
    Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ...
  • Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal 

    Heffron, Cynthia Constance Bridgette Beatrice (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)
    Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ...