Browsing Histopathology & Morbid Anatomy by Title
Now showing items 1-20 of 105
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A 39kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome.
(John Wiley, 2008)Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ... -
A therapeutic roadmap for ovarian cancer using TLR4 MyD88 and MAD2 as prognostic indicators
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2016)Ovarian cancer is 4th leading cause of cancer death in woman and the most lethal gynaecological malignancy. Most patients present with advanced disease where the 5 year survival rate is less than 40%. Standard treatment ... -
Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum.
(1994)A 12 amino acid sequence from the adenovirus 12 E1B protein is homologous at the protein level with a similar 12-mer derived from the wheat protein A-gliadin. It has been suggested that exposure to Ad 12 could sensitise ... -
Application of statistical process control to qualitative molecular diagnostic assays.
(2014)Modern pathology laboratories and in particular high throughput laboratories such as clinical chemistry have developed a reliable system for statistical process control (SPC). Such a system is absent from the majority of ... -
Aspirin and P2Y<inf>12</inf> inhibition attenuate platelet-induced ovarian cancer cell invasion
(2015)Background: Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian ... -
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
(2010)Although B-Raf(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC), how it induces tumor aggressiveness is not fully understood. Using gene set enrichment analysis and in vitro and in vivo ... -
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
(2013)Mutations in BRCA1/2 increase the risk of developing breast and ovarian cancer. Germline BRCA1/2 mutations occur in 8.6-13.7% of unselected epithelial ovarian cancers, somatic mutations are also frequent. BRCA1/2 mutated ... -
BRCA1/2 mutation analysis in 43 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation
(2012)Introduction: Germline mutations in DNA repair genes BRCA1/2 increase the risk of developing breast and ovarian cancer. Germline BRCA1/2 mutations occur in 8.6-13.7% of unselected epithelial ovarian cancers, somatic mutations ... -
C-ABL in human cancer: an investigation of its role in apoptosis inhibition, differentiation and angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)Research over the past number of decades has significantly advanced our understanding of the cell signalling effects that mediate a diverse array of cellular activities including cell proliferation, homeostasis and ... -
Cancer cell-platelet interactions in ovarian cancer metastasis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the leading cause of death from gynaecological malignancy worldwide with an estimated global incidence of 225,900 and mortality of 140,200 per year. In Ireland ovarian cancer is the second most common ... -
Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ... -
Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells
(2014)A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is ... -
Catching moving targets: Cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention
(2017)It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted efforts, ... -
A cloud computing database for data extraction in a Cochrane review
(2013)Background: An online database was needed for the Cochrane review ?Taxanes for the treatment of platinum pre-treated epithelial ovarian cancer? for several reasons. Firstly, a large amount of clinical parameters were to ... -
Control of reproductive floral organ identity specification in Arabidopsis by the C function regulator AGAMOUS.
(2013)The floral organ identity factor AGAMOUS (AG) is a key regulator of Arabidopsis thaliana flower development, where it is involved in the formation of the reproductive floral organs as well as in the control of meristem ... -
Corpus of Works submitted for Doctor of Science (Sc.D.)
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023) -
Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.
(2011)Cervical cancer, a potentially preventable disease, has its main aetiology in infection by high risk human papillomavirus (HR-HPV). Approaches to improving cervical cancer screening and diagnostic methodologies include ...