The complex relationship of gene duplication and essentiality.

Mc Lysaght, Aoife; Hokamp, Karsten

dc.contributor.author	Mc Lysaght, Aoife	en
dc.contributor.author	Hokamp, Karsten	en
dc.date.accessioned	2011-08-16T14:43:24Z
dc.date.available	2011-08-16T14:43:24Z
dc.date.issued	2009	en
dc.date.submitted	2009	en
dc.identifier.citation	Makino, T, Hokamp, K, McLysaght, A, The complex relationship of gene duplication and essentiality., Trends in genetics, 25, 4, 2009, 152 - 155	en
dc.identifier.issn	0168-9525	en
dc.identifier.other	Y	en
dc.identifier.uri	http://hdl.handle.net/2262/58715
dc.description	PUBLISHED	en
dc.description.abstract	In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.	en
dc.description.sponsorship	We would like to thank Yoichiro Nakatani for supplying lists of the WGD duplicated genes and all the members of the McLysaght laboratory for helpful discussions. This work is supported by Science Foundation Ireland.	en
dc.format.extent	152	en
dc.format.extent	155	en
dc.language.iso	en	en
dc.relation.ispartofseries	Trends in genetics	en
dc.relation.ispartofseries	25	en
dc.relation.ispartofseries	4	en
dc.rights	Y	en
dc.subject	Genetics	en
dc.subject	singleton gene	en
dc.title	The complex relationship of gene duplication and essentiality.	en
dc.type	Journal Article	en
dc.type.supercollection	scholarly_publications	en
dc.type.supercollection	refereed_publications	en
dc.identifier.peoplefinderurl	http://people.tcd.ie/mclysaga	en
dc.identifier.peoplefinderurl	http://people.tcd.ie/kahokamp	en
dc.identifier.rssinternalid	56268	en
dc.identifier.doi	http://dx.doi.org/10.1016/j.tig.2009.03.001	en
dc.subject.TCDTheme	Genes & Society	en
dc.identifier.rssuri	http://dx.doi.org/10.1016/j.tig.2009.03.001	en
dc.identifier.orcid_id	0000-0003-2552-6220	en