Browsing Medical Gerontology by Title
Now showing items 238-257 of 372
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Maternal educational inequalities in measured body mass index trajectories in three European countries
(2019)Background: Social inequalities in the prevalence of childhood overweight and obesity are well‐established, but less is known about when the social gradient first emerges and how it evolves across childhood and ... -
A mathematical model of ageing-related and cortisol induced hippocampal dysfunction.
(BioMed Central, 2009)Background The hippocampus is essential for declarative memory synthesis and is a core pathological substrate for Alzheimer's disease (AD), the most common aging-related dementing disease. Acute increases in plasma cortisol ... -
Mature Matters: Ageing
(Irish Independent, 2012)Article appeared in the Irish Independent 04/07/2011 -
Mayer Wave Activity in Vasodepressor Carotid Sinus Hypersensitivity
(2010)Aims Mayer waves are low frequency blood pressure waves, whose modulation involves central/peripheral baroreflex pathways. Although vasodepressor carotid sinus hypersensitivity (VDCSH) is a common hypotensive disorder in ... -
Measuring Frailty using Self-report and Test-based Health Measures.
(2015)Background: previously, frailty indices were constructed using mostly subjective health measures. The reporting error in this type of measure can have implications on the robustness of frailty findings. Objective: to ... -
Metabolic syndrome accelerates epigenetic ageing in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA).
(2023)Metabolic syndrome (MetS) is a risk factor for the development of diabetes, cardiovascular disease, and all-cause mortality. It has an estimated prevalence of 40 % among older adults. Epigenetic clocks, which measure ... -
Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis
(2021)Background: It has been postulated that metformin could have anti-SARS-CoV-2 action. This raises the hypothesis that people who take metformin may have lower SARS-CoV-2 severity and/or mortality. Objective To conduct a ... -
A mixed-methods feasibility study of a sit-to-stand based exercise programme to maintain knee-extension muscle strength for older patients during hospitalisation
(2021)Objectives: To determine the acceptability of an exercise programme and to identify barriers and facilitators to compliance with the programme from the participants’ perspective. Methods: Patients ... -
Mortality in relation to changes in a healthy aging index: The health, aging, and body composition study
(2019-04)Background: Baseline scores on a Healthy Aging Index (HAI), including five key physiologic domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship ... -
Multiple medication use in the middle and older age population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)Polypharmacy in the older population is increasingly common and can represent necessary preventative therapies or potential inappropriate prescribing and be a risk factor for falls. In addition, medications with anti-cholinergic ... -
Multiprofessional Views on Older Patients' Participation in Care Planning Meetings in a Hospital Context
(2013)Care planning meetings (CPMs; sometimes referred to as family meetings) for older patients involve group decision-making between the multidisciplinary team, the older person and their family. However, service user participation ... -
Negative perceptions of aging and decline in walking speed: A self-fulfilling prophecy
(2015)Introduction Walking speed is a meaningful marker of physical function in the aging population. While it is a primarily physical measure, experimental studies have shown that merely priming older adults with negative ... -
Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults
(2021)In this Specialty Grand Challenge, we outline our vision of the current challenges in the field of Network Physiology as applied to aging and frailty. An expected development in this field for the 21st century is the ... -
Neuroimaging referral for dementia diagnosis: The specialist s perspective in Ireland
(2015)Background: Neuroimaging is an increasingly important tool in the diagnostic workup of dementia. Neurologists, geriatricians, and old-age psychiatrists are involved in key tasks in the diagnostic pro- cess, frequently ... -
New Horizons in Frailty: the contingent, the existential and the clinical
(2019)In the past decade, frailty research has focused on refinement of biomedical tools and operationalisations, potentially introducing a reductionist approach. This article suggests that a new horizon in frailty lies in a ... -
New Insights and Knowledge on Cognition and Dementia from Population-Based Cohort of Older Adults in India.
(2020)The Longitudinal Aging Study in India (LASI) is the world's largest aging survey, a groundbreaking nationally representative longitudinal survey to examine aging and retirement among India's aged 45 and older population. ... -
New self-reported exhaustion during the COVID-19 Pandemic
(2021)In 2020, participants from The Irish Longitudinal Study on Ageing were surveyed to provide vital and timely information on lived experiences of older adults during the SARS-CoV-2 pandemic. During 2020, older adults experienced ... -
NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer's disease.
(2014)This study is a European multicentre, randomised, double-blind, placebo-controlled trial investigating the efficacy and safety of nilvadipine as a disease course modifying treatment for mild-to-moderate Alzheimer's disease ... -
Nilvadipine in mild to moderate Alzheimer's disease: a randomised controlled trial.
(2018)Background: This study reports the findings of the first large-scale Phase III investigator-driven clinical trial to slow the rate of cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel ...