dc.contributor.author | MOLLOY, ANNE MARIE | en |
dc.contributor.author | SCOTT, JOHN MARTIN | en |
dc.date.accessioned | 2009-11-04T09:26:30Z | |
dc.date.available | 2009-11-04T09:26:30Z | |
dc.date.issued | 2007 | en |
dc.date.submitted | 2007 | en |
dc.identifier.citation | L. Hoey, H. McNulty, N. Askin, A. Dunne, M. Ward, K. Pentieva, J. Strain, A.M. Molloy, C.A. Flynn, J.M. Scott. , Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults., American Journal of Clinical Nutrition, 86, 5, 2007, 1405 - 1413 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/34486 | |
dc.description | PUBLISHED | en |
dc.description | PubMed ID: 17991653 | en |
dc.description.abstract | Background: Mandatory folic acid fortification of food is effective in reducing neural tube defects and may even reduce stroke-related mortality, but it remains controversial because of concerns about potential adverse effects. Thus, it is virtually nonexistent in Europe, albeit many countries allow food fortification on a voluntary basis.
Objective: The objective of the study was to examine the effect of a voluntary but liberal food fortification policy on dietary intake and biomarker status of folate and other homocysteine-related B vitamins in a healthy population.
Design: The study was a cross-sectional study. From a convenience sample of 662 adults in Northern Ireland, those who provided a fasting blood sample and dietary intake data were examined (n = 441, aged 18?92 y). Intakes of both natural food folate and folic acid from fortified foods were estimated; we used the latter to categorize participants by fortified food intake.
Results: Fortified foods were associated with significantly higher dietary intakes and biomarker status of folate, vitamin B-12, vitamin B-6, and riboflavin than were unfortified foods. There was no difference in natural food folate intake (range: 179?197 ?g/d) between the fortified food categories. Red blood cell folate concentrations were 387 nmol/L higher and plasma total homocysteine concentrations were 2 ?mol/L lower in the group with the highest fortified food intake (median intake: 208 ?g/d folic acid) than in the nonconsumers of fortified foods (0 ?g/d folic acid).
Conclusions: These results show that voluntary food fortification is associated with a substantial increase in dietary intake and biomarker status of folate and metabolically related B vitamins with potential beneficial effects on health. However, those who do not consume fortified foods regularly may have insufficient B vitamin status to achieve the known and potential health benefits. | en |
dc.format.extent | 1405 | en |
dc.format.extent | 1413 | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.relation.ispartofseries | American Journal of Clinical Nutrition | en |
dc.relation.ispartofseries | 86 | en |
dc.relation.ispartofseries | 5 | en |
dc.rights | Y | en |
dc.subject | Food fortification ? folate ? folic acid ? plasma homocysteine ? B vitamins ? intakes ? biomarkers ? dietary folate equivalents ? adults | en |
dc.title | Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/amolloy | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/jscott | en |
dc.identifier.rssinternalid | 50221 | en |