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dc.contributor.authorKELLY, DANIEL
dc.contributor.authorPrendergast, Patrick John
dc.date.accessioned2009-04-14T17:29:22Z
dc.date.available2009-04-14T17:29:22Z
dc.date.issued2006
dc.date.submitted2006en
dc.identifier.citationKelly D.J. and Prendergast P.J. `Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair? in Tissue Engineering, 12, (9), 2006, pp 2509 - 2519en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/29149
dc.descriptionPUBLISHEDen
dc.description.abstractThe optimal mechanical properties of a scaffold to promote cartilage generation in osteochondral defects in vivo are not known. During normal daily activities cartilage is subjected to large cyclic loads that not only facilitate nutrient transport and waste removal through the dense tissue but also act as a stimulus to the chondrocytes. In contrast, cartilage tissue is commonly engineered in vitro in a static culture and hence, in many cases, the properties of scaffolds have been tailored to suit this in vitro environment. In this study, a mechano-regulation algorithm for tissue differentiation has been used to determine the influence scaffold material properties on chondrogenesis in a finite element model of an osteochondral defect. It is predicted that increasing the stiffness of the scaffold increases the amount of cartilage formation and reduces the amount of fibrous tissue formation in the defect, but this only holds true up to a certain threshold stiffness above which the amount of cartilage formed is reduced. Reducing the permeability of the scaffold was also predicted to be beneficial. Considering a nonhomogenous scaffold, an optimal design was determined by parametrically varying the mechanical properties of the scaffold through its depth. The Young?s modulus reduced non-linearly from the superficial region through the depth of the scaffold, while the permeability of the scaffold was lowest in the superficial region. As tissue engineering moves from a science towards a product, engineering design becomes more relevant, and predictive models such as that presented here can provide a scientific basis for design choices.en
dc.description.sponsorshipThis work was funded by the European Union (EU) under the BITES project (Contract #: QLK3-CT-1999-00559).en
dc.format.extent2509en
dc.format.extent2519en
dc.format.extent4298110 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherMary Ann Lieberten
dc.relation.ispartofseriesTissue Engineeringen
dc.relation.ispartofseries12en
dc.relation.ispartofseries9en
dc.rightsYen
dc.subjectMesenchymal Stem Cellsen
dc.subjectFundamentals of Tissue Engineeringen
dc.titlePrediction of optimal mechanical properties for a scaffold used in osteochondral defect repairen
dc.typeJournal Articleen
dc.contributor.sponsorEuropean Union (EU)
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pprender
dc.identifier.rssinternalid34507
dc.identifier.rssurihttp://www.liebertonline.com/doi/pdf/10.1089/ten.2006.12.2509


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