Browsing School of Genetics & Microbiology by Title
Now showing items 613-632 of 873
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The phenotypic plasticity of duplicated genes in Saccharomyces cerevisiae and the origin of adaptations
(2017)Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of ... -
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Picking the high hanging fruit : automated ways to annotate awkward genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)In Chapter 2 I describe the development of software called SearchDOGS (Database of Orthologous Genomic Segments). By identifying regions of conserved local synteny across species using the synteny information contained in ... -
Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products
(2010)Macrophages are involved in many aspects of development, host defense, pathology, and homeostasis. Their normal differentiation, proliferation, and survival are controlled by CSF-1 via the activation of the CSF-1R. A ... -
Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
(Elsevier, 2009)We have selected piperaquine (PQ) and lumefantrine (LM) resistant Plasmodium berghei ANKA parasite lines in mice by drug pressure. Effective doses that reduce parasitaemia by 90% (ED90) of PQ and LM against the parent line ... -
Plasticity of recurrent inhibition in the Drosophila antennal lobe
(2012)Recurrent inhibition, wherein excitatory principal neurons stimulate inhibitory interneurons that feedback on the same principal cells, occurs ubiquitously in the brain. However, the regulation and function of recurrent ... -
Platelet activation by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is the leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is thought to be an important step in the pathogenesis ... -
Plxdc2 is a mitogen for neural progenitors
(2011)The development of different brain regions involves the coordinated control of proliferation and cell fate specification along and across the neuraxis. Here, we identify Plxdc2 as a novel regulator of these processes, using ... -
The PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p
(2012)Yeast histone mRNAs are polyadenylated, yet factors such as Rrp6p and Trf4p, required for the 3?-end processing of non-polyadenylated RNAs, contribute to the cell cycle regulation of these transcripts. Here, we investigated ... -
Polycomb group proteins: navigators of lineage pathways led astray in cancer
(2009)The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell ... -
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
(2012)Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional ... -
Population and genomic variation of immune genes in chicken
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Achieving an understanding of the processes shaping diversity at chicken immune genes illuminates their population history, relevance to disease and mechanisms of evolution. Functional variation at genes that determine the ... -
Population genetics of modern and ancient cattle
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)The domestication of cattle was a milestone in human history. It is widely accepted that cattle were domesticated in at least two independent domestication events; the Fertile Crescent was the primary domestication centre ... -
The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods
(2017)We analyse new genomic data (0.05–2.95x) from 14 ancient individuals from Portugal distributed from the Middle Neolithic (4200–3500 BC) to the Middle Bronze Age (1740–1430 BC) and impute genomewide diploid genotypes in ... -
Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples
(2021)Candida tropicalis is a human pathogen that primarily infects the immunocompromised. Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in 2009, there have been no large-scale, multi-isolate ... -
Porter: a new, accurate server for protein secondary structure prediction
(Oxford University Press, 2005)Porter is a new system for protein secondary structure prediction in three classes. Porter relies on bidirectional recurrent neural networks with shortcut connections, accurate coding of input profiles obtained from multiple ... -
Positionally biased gene loss after whole genome duplication: evidence from human, yeast, and plant.
(2012)Whole genome duplication (WGD) has made a significant contribution to many eukaryotic genomes including yeast, plants and vertebrates. Following WGD, some ohnologs (WGD paralogs) remain in the genome arranged in blocks ... -
Post-polyploidy evolution in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)Whole-genome duplication (WGD) and gene duplication are topics central to the study of genome evolution. With the availability of genome sequences for both paleopolyploid (post-WGD) and non-polyploid outgroup (pre-WGD) ...