Browsing School of Genetics & Microbiology by Title
Now showing items 328-347 of 873
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Genetic evidence of African slavery at the beginning of the Trans-Atlantic slave trade
(2014)An archaeological excavation in Valle da Gafaria (Lagos, Portugal), revealed two contiguous burial places outside the medieval city walls, dating from the 15th-17th centuries AD: one was interpreted as a Leprosarium cemetery ... -
Genetic evidence that bound coagulase of Staphylococcus aureus is not clumping factor
(1992)Staphylococcus aureus Newman cells carry a surface receptor for fibrinogen called clumping factor. The bacteria also express coagulase, an extracellular protein that binds to prothrombin to form a complex with thrombinlike ... -
Genetic heterogeneity in amyotrophic lateral sclerosis and related disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The overarching aim of this thesis is to clarify and further our understanding of the genetic causes of amyotrophic lateral sclerosis (ALS) and related diseases. It is hoped that achieving this can help bring clarity to ... -
Genetic investigation of Irish ancestry and surname history
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ... -
Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)One of the main functions of the brain is to process information from the environment. All input to the neocortex passes through the thalamus in order to be handled. Therefore, proper connectivity between the thalamus and ... -
Genetic resistance to Campylobacter jejuni colonization in the chicken
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Campylobacter colonization levels within the chicken gastrointestinal tract vary substantially between individual chickens and this variation in colonization susceptibility can be heritable. In this work the genetic ... -
Genetic structure and trait estimation in ancient Europeans
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)The study of ancient human populations have mostly been carried out, until recently, by historians through the study of written records and ancient manufacts. Thanks to recent technological and theoretical advancements in ... -
Genetic variation in domesticated cattle and wild aurochsen using ancient and modern data
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)A total of 101 Bos taurus teeth and bones aged between 1,000 to 9,000 years old, and 45 B. primigenius primigenius bones aged between 3,720 to 12,380 years old, were assessed for the presence of verifiable mitochondrial ... -
Genetic variation in the bovine genome : signatures of selection and demographic history
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Domestication, and its associated environmental and demographic changes, undoubtedly brought new challenges to early domesticates, such as cattle. One of the most important would have been the emergence of new disease ... -
The genetics of brain wiring: from molecule to mind.
(2007)What makes some people neurotic or schizophrenic or right-handed or fearless? Are these behavioural differences caused by literal differences in how individuals' brains are wired? If so, what causes those differences? This ... -
Genetics of calving performance
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Calving performance is a significant contributor to the profitability of cattle production systems whilst also becoming an increasingly important welfare issue in recent years. Calving performance includes both dystocia ... -
The genetics of neurodevelopmental disease
(Elsevier, 2011)The term neurodevelopmental disorder encompasses a wide range of diseases, including recognizably distinct syndromes known to be caused by very rare mutations in specific genes or chromosomal loci, and also much more common ... -
Genome architecture and global transcriptional control in bacteria: making progress towards a unified model?
(2013)Data obtained with advanced imaging techniques, chromosome conformation capture methods, bioinformatics and molecular genetics, together with insights from polymer physics and mechanobiology, are helping to refine our ... -
Genome sequencing and functional genomics in Bacillus subtilis : the expression and roles of the superoxide dismutases and NADH dehydrogenases
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)The work in this thesis spans genome sequencing of Bacillus subtilis, functional analysis of genes of unknown function and more detailed characterisation of the function and regulation of specific genes. Approximately 0.7% ... -
Genome survey sequencing of the wine spoilage yeast Dekkera (Brettanomyces) bruxellensis.
(American Society for Microbiology, 2007)The hemiascomycete yeast Dekkera bruxellensis, also known as Brettanomyces bruxellensis, is a major cause of wine spoilage worldwide. Wines infected with D. bruxellensis develop distinctive, unpleasant aromas due to volatile ... -
A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle
(2012)BACKGROUND: Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and ... -
Genome-wide analysis of gene expression during early Arabidopsis flower development
(Public Library of Science, 2006)Detailed information about stage-specific changes in gene expression is crucial for the understanding of the gene regulatory networks underlying development. Here, we describe the global gene expression dynamics during ...