Browsing Pharmaceutics & Pharmaceutical Technology (Theses and Dissertations) by Title
Now showing items 4-11 of 11
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In vivo and in vitro mechanistic studies on targeting of lipophilic compounds to the intestinal lymphatics using lipid-based vehicles
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The aim of the experiments conducted in this thesis was to investigate the effect of a range of lipid-based vehicles on the intestinal lymphatic transport of triglycerides and of two lipophilic compounds- DDT and cyclosporine, ... -
Novel formulations for use in the oral cavity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The aim of this thesis was to develop a number of novel products for use in the oral cavity. Periodontitis is a condition characterized by the loss of clinical attachment to the gum, along with resorption of the alveolar ... -
Novel pharmaceutical excipients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The research work performed in compiling this thesis can be divided into two broad areas, namely (a) the development, characterisation and examination of potential pharmaceutical applications of new de-aggregated grades ... -
Potential applications of halloysite for improved topical drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this thesis was to evaluate the potential application of halloysite, an aluminosilicate clay material, for use in topical and transdermal drug delivery. Halloysite is a tubular material, the hollow lumen has ... -
Potential pharmaceutical applications of sepiolite
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The focus of the research presented in this thesis was on the potential pharmaceutical applications of sepiolite from the Vallecas-Vicalvaro region in Spain. Initial studies involved extensive characterisation of sepiolite ... -
The use of the Caco-2 cell culture model to investigate lipid vehicle effects on lipid metabolism and drug permeation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The aim of this thesis was to assess the usefulness of the Caco-2 model for screening lipid vehicle excipient effects on intestinal lipoprotein production and secretion, with emphasis on chylomicron secretion. In addition, ... -
Transdermal delivery of somatostatin analogues
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The aim of this work was to develop transdermal delivery systems for the administration of two peptidic somatostatin analogues, BIM-23014 and its higher potency analogue BIM-23190. Due to its ability to suppress growth ... -
Use of halloysite for agrochemical applications
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The focus of this thesis was to develop two products for use in agrochemical applications, using the naturally occurring microtubular mineral, halloysite. Firstly, it was necessary to obtain a highly tubular grade of the ...
