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  • Novel pharmaceutical excipients 

    Levis, Shane Reed (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)
    The research work performed in compiling this thesis can be divided into two broad areas, namely (a) the development, characterisation and examination of potential pharmaceutical applications of new de-aggregated grades ...
  • Transdermal delivery of somatostatin analogues 

    Loughman, Thomas Ciarán (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)
    The aim of this work was to develop transdermal delivery systems for the administration of two peptidic somatostatin analogues, BIM-23014 and its higher potency analogue BIM-23190. Due to its ability to suppress growth ...
  • Development of novel cyclodextrins as non-viral gene delivery vectors and assessment of differentiated cell culture models to predict in vivo gene expression 

    Cryan, Sally-Ann (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)
    The aims of this thesis were to examine the use of differentiated cell culture systems in the in vitro assessment of non-viral gene delivery systems and to investigate the use of commercial and novel cyclodextrins as vectors ...
  • Novel formulations for use in the oral cavity 

    Kelly, Helena Mary (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)
    The aim of this thesis was to develop a number of novel products for use in the oral cavity. Periodontitis is a condition characterized by the loss of clinical attachment to the gum, along with resorption of the alveolar ...
  • Characterisation and use of porous aluminosilicate pellets for extended drug delivery 

    Byrne, Robert Stephen (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)
    The initial focus of the research presented in this thesis was on the potential applications of a number of pelletized porous ceramics in drug delivery. These were commercially produced and were marketed for use in the ...
  • The use of the Caco-2 cell culture model to investigate lipid vehicle effects on lipid metabolism and drug permeation 

    Seeballuck, Fergal (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)
    The aim of this thesis was to assess the usefulness of the Caco-2 model for screening lipid vehicle excipient effects on intestinal lipoprotein production and secretion, with emphasis on chylomicron secretion. In addition, ...
  • Use of halloysite for agrochemical applications 

    Salter, Anne Elizabeth (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)
    The focus of this thesis was to develop two products for use in agrochemical applications, using the naturally occurring microtubular mineral, halloysite. Firstly, it was necessary to obtain a highly tubular grade of the ...
  • Potential applications of halloysite for improved topical drug delivery 

    Ryan, Catherine (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)
    The aim of this thesis was to evaluate the potential application of halloysite, an aluminosilicate clay material, for use in topical and transdermal drug delivery. Halloysite is a tubular material, the hollow lumen has ...
  • Potential pharmaceutical applications of sepiolite 

    Deasy, Alecia Rowena (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)
    The focus of the research presented in this thesis was on the potential pharmaceutical applications of sepiolite from the Vallecas-Vicalvaro region in Spain. Initial studies involved extensive characterisation of sepiolite ...
  • Factors affecting the pharmacotherapeutic management of chronic non-malignant pain in ageing and elderly populations in Ireland 

    Kennedy, Mary-Claire (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)
    Chronic non-malignant pain (CNMP) has emerged as a global health priority due to the prevalence, complexity and presentation of the condition across all age- groups, social classes and ethnicities. There is a high prevalence ...