Browsing Clinical Medicine (Scholarly Publications) by Sponsor "Wellcome Trust"
Now showing items 1-11 of 11
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A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations
(Springer, 2005)Substantial evidence suggests that a low folate/high homocysteine phenotype is pathogenic. We analyzed the impact of the thymidylate synthase (TYMS) 3UTR ins/del polymorphism on folate and homocysteine levels and assessed ... -
Decoy receptors in the regulation of T Helper cell type 2 response
(The Rockefeller University Press, 2003) -
Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
(2011)OBJECTIVE: /st> There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct ... -
Helminth infection protects mice from anaphylaxis via IL-10 producing B cells
(The American Association of Immunologists, 2004)Modulation of the immune system by infection with helminth parasites, including schistosomes, is proposed to reduce the levels of allergic responses in infected individuals. In this study we investigated whether experimental ... -
Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism.
(The American Association of Immunologists, 2007)The propensity of a range of parasitic helminths to stimulate a Th2 or regulatory cell-biased response has been proposed to reduce the severity of experimental inflammatory bowel disease. We examined whether infection with ... -
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
(2013)Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce ... -
SIGN-R1 contributes to protection against lethal pneumococcal infection in mice
(Rockefeller University Press, 2004)Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 ... -
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
(2011)The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by ... -
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
(2013)BACKGROUND: Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier ...