Browsing Clinical Medicine (Scholarly Publications) by Author "Volkov, Yuri"
Now showing items 1-11 of 11
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Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease
Volkov, Yuri; Movia, Dania; Gounko, Iouri (2018) -
Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
HANNON, GARY; Bogdanska, Anna; Volkov, Yuri; Prina-Mello, Adriele (2020)Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials ... -
A complex morphofunctional approach for zinc toxicity evaluation in rats
Volkov, Yuri (2020)Anthropogenic activity causes the introduction of zinc compounds into the biological cycle in mining and processing sites and its accumulation in organs and tissues, causing systemic toxicity. A cumulative effect of zinc ... -
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
Long, Aideen; Petrovic, Danijela; Stamataki, Zania; Dempsey, Eugene; Golden-Mason, Lucy; Freeley, Michael; Doherty, Derek; Prichard, David; Keogh, Catherine; Conroy, Jennifer; Mitchell, Siobhan; Volkov, Yuri; McKeating, Jane A.; O'Farrelly, Cliona; Kelleher, Dermot (2011)T cell activation and the resultant production of interleukin (IL-2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses sev- eral mechanisms to evade both the ... -
Induction of protein citrullination and auto-antibodies production in murine exposed to nickel nanomaterials.
Volkov, Yuri; Gray, Steven; Prina Mello, Adriele (2018) -
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
Volkov, Yuri; Kelleher, Dermot; Long, Aideen; Fallon, Padraic; Verma, Navin K.; Dempsey, Eugene; Davies, Anthony; Barry, Sean P. (2012)The immunesuppressive cytokine TGF-β plays crucial regulatory roles in the induction and maintenance of immunologic tolerance and prevention of immunopathologies. However, it remains unclear how circulating T-cells can ... -
Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs
Volkov, Yuri; Movia, Dania; Volkov, Yuri; Prina-Mello, Adriele (2018)Evidence supports the advantages of inhalation over other drug-administration routes in the treatment of lung diseases, including cancer. Although data obtained from animal models and conventional in vitro cultures are ... -
Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes
Prina Mello, Adriele; Volkov, Yuri (2020)Carbon‐based nanomaterials (C‐BNM) have recently attracted an increased attention as the materials with potential applications in industry and medicine. Bioresistance and proinflammatory potential of C‐BNM is the main ... -
Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents
Smith, Stephen; Volkov, Yuri; Prina Mello, Adriele (2018)Silver nanoparticle-based antimicrobials can promote a long lasting bactericidal effect without detrimental toxic side effects. However, there is not a clear and complete protocol to define and relate the properties of ... -
STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL
Long, Aideen; Verma, Navin K.; Davies, Anthony M.; Kelleher, Dermot; Volkov, Yuri (2010)Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas resulting from clonal expansion and localization of malignant T-lymphocytes to the skin. CTCL cells have defective ... -
Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials
Volkov, Yuri; Movia, Dania; Prina Mello, Adriele; Di Cristo, Luisana; Maguire, Ciaran Manus; McQuillan, Karen; Alleardi, Mattia (2018)Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by nebulization or using pressurized metered dose inhalers, and in solid form by means of dry powder inhalers. However, NP ...