Browsing Clinical Medicine (Scholarly Publications) by Author "Verma, Navin K."
Now showing items 1-3 of 3
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Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
Volkov, Yuri; Kelleher, Dermot; Long, Aideen; Fallon, Padraic; Verma, Navin K.; Dempsey, Eugene; Davies, Anthony; Barry, Sean P. (2012)The immunesuppressive cytokine TGF-β plays crucial regulatory roles in the induction and maintenance of immunologic tolerance and prevention of immunopathologies. However, it remains unclear how circulating T-cells can ... -
Phosphorylation of Rab5a protein by protein kinase Cϵ Is crucial for T-cell migration
Long, Aideen; Ong, Seow Theng; Freeley, Michael; Skubis-Zegladło, Joanna; Hussain Urf Turabe Fazil, Mobashar; Kelleher, Dermot; Fresser, Friedrich; Baier, Gottfried; Verma, Navin K. (2014)Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ... -
STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL
Long, Aideen; Verma, Navin K.; Davies, Anthony M.; Kelleher, Dermot; Volkov, Yuri (2010)Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas resulting from clonal expansion and localization of malignant T-lymphocytes to the skin. CTCL cells have defective ...