Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 603-622 of 638
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Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials
(2018)Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by nebulization or using pressurized metered dose inhalers, and in solid form by means of dry powder inhalers. However, NP ... -
Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects.
(2010)Objective Women who have low cobalamin (vitamin B12) levels are at increased risk for having children with neural tube defects (NTDs). The transcobalamin II receptor (TCblR) mediates uptake of cobalamin into cells. ... -
Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.
(2011)Two polymorphic variants in the gene coding for transcobalamin II ( TCN2 ), TCN2 776C- . Gand TCN2 67A- . G, may alter serum holotranscobalamin (holoTC), which in turn may affect cellular uptake of cobalamin ... -
Transcriptional regulator PRDM12 is essential for human pain perception.
(2015)Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which ... -
Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFN? Regulation.
(2015)Genetic studies have to date identified 43 genome wide significant coeliac disease susceptibility (CD) loci comprising over 70 candidate genes. However, how altered regulation of such disease associated genes contributes ... -
Treatment of Helicobacter pylori Infection 2011
(2011)This article reviews the literature published pertaining to Helicobacter pylori eradication over the last year. The general perception among clinicians and academics engaged in research on H. pylori has been that eradication ... -
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF?B and Autophagy Dependent Bacillary Killing
(2016)The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has increased the urgency to develop novel treatment modalities, ... -
Troponin status predicts 30-day in-hospital mortality
(2020)Aim: To evaluate the prognostic value of high-sensitivity cardiac troponin (hscTnT) levels in unselected emergency medical admissions. Methods: We report on all hscTnT tests in emergency medical admissions, ... -
The Two Hit Hypothesis: An Improved Method for siRNA-Mediated Gene Silencing in Stimulated Primary Human T Cells.
(2013)Small interfering RNAs (siRNAs) have revolutionised cellular and molecular biology by uncovering new roles for genes in various biological processes and by providing new opportunities to silence gene expression for therapeutic ... -
Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism
(2017)Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids ... -
Uncoupling protein 2 polymorphisms as risk factors for NTDs
(2009)Both environmental and genetic factors are involved in the etiology of neural tube defects (NTDs). Inadequate folate intake and obesity are important environmental risk factors. Several folate-related genetic variants have ... -
Understanding and exploiting the effect of tuberculosis antimicrobials on host mitochondrial function and bioenergetics
(2020)Almost 140 years after its discovery, tuberculosis remains the leading infectious cause of death globally. For half a century, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and ... -
Unequal rates of Y chromosome gene divergence during speciation of the family Ursidae.
(2008)Evolution of the bear family Ursidae is well investigated in terms of morphological, paleontological, and genetic features. However, several phylogenetic ambiguities occur within the subfamily Ursinae (the family Ursidae ... -
Untreated chronic tuberculous salpingitis followed by successful in vitro fertilization conception and congenital tuberculosis
(2015)Female reproductive tract tuberculosis is rarein the developed world and its diagnosis ischallenging. However, this case illustrates theimportance of including female reproductivetract tuberculosis in the differential for ... -
Untreated Chronic Tuberculous Salpingitis followed by successful IVF Conception and Congenital Tuberculosis.
(2015)Female reproductive tract tuberculosis is rare in the developed world and its diagnosis is challenging. However, this case illustrates the importance of including female reproductive tract tuberculosis in the differential ... -
Ursodeoxycholic acid attenuates colonic epithelial secretory function.
(2013)Dihydroxy bile acids, such as chenodeoxycholic acid (CDCA), are well known to promote colonic fluid and electrolyte secretion, thereby causing diarrhoea associated with bile acid malabsorption. However, CDCA is rapidly ... -
Using Action Research and Peer Perspectives to Develop Technology That Facilitates Behavioral Change and Self-Management in COPD
(2014)Background. Behavioural change and self-management in patients with chronic illness may help to control symptoms, avoid rehospitalization, enhance quality of life, and decrease mortality and morbidity. Objective. Guided ...