Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 142-161 of 638
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Development of an automated MRI-based diagnostic protocol for amyotrophic lateral sclerosis using disease-specific pathognomonic features: A quantitative disease-state classification study
(2016)Background Despite significant advances in quantitative neuroimaging, the diagnosis of ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis. The objective of this study is to develop ... -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
(2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
Development of significant disease in a cohort of patients with non-specific enteritis on capsule endoscopy: clinical suspicion and a high base line Lewis score are predictive of Crohn's disease.
(2020)Background: As with isolated ileitis the findings of nonspecific small bowel enteritis (NSE) on capsule endoscopy (CE) poses a clinical challenge. There is lack of available evidence to help clinicians to predict significant ... -
Development of SIRT1 siRNA-carrying liposomes for treatment of prostate cancer
(2020)Sirtuin 1 (SIRT1) is a histone deacetylase (HDAC) from Sirtuin family and high expression of it induces activation of DNA repairing factors eventually leading either tumor suppression or tumor development in cellular ... -
Diabetes mellitus and apoptosis:inflammatory cells
(2009)Since the early observation that similarities between thyroiditis and insulitis existed, the important role played by inflammation in the development of diabetes has been appreciated. More recently, experiments have shown ... -
Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk
(2012)Objective: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel cardiometabolic risk factor. Whether dietary fat intake ... -
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett?s oesophagus?.
(2014)Contemporary clinical management of Barrett's oesophagus has highlighted the lack of accurate predictive markers of disease progression to oesophageal cancer. This study aims to examine alterations in mitochondrial energy ... -
Differential expression profiles of oxidative stress levels, 8-oxo-dG and 4-HNE, in Barrett?s esophagus compared to esophageal adenocarcinoma
(2019)Barrett’s esophagus (BE), a chronic inflammatory condition, is the leading risk factor for esophageal adenocarcinoma (EAC). In inflammation to cancer pathways, oxidative stress profiles have been linked to cancer progression. ... -
Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles
(2014)Therapeutic engineered nanoparticles (NPs), including ultrasmall superparamagnetic iron oxide (USPIO) NPs, may accumulate in the lower digestive tract following ingestion or injection. In order to evaluate the reaction of ... -
Disorders of keratinisation: from rare to common genetic diseases of skin and other epithelial tissues.
(PubMed, 2007)Epithelia are the first line of defence between the human body and its environment. For example, the skin, the largest organ in the body, is covered by the epidermis ? a multilayered, stratified, cornified epithelium that ... -
Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?
(2011)ABSTRACT Background: In elderly individuals with low serum vitamin B-12, those who have high serum folate have been reported to have greater abnormalities in the following biomarkers for vitamin B-12 defi- ciency: low ... -
Driving cessation in patients attending a memory clinic.
(2005)BACKGROUND: Driving is an increasingly important form of transport for older people. Dementia is common in later life and will eventually lead to driving cessation, which reduces the public health risk of impaired driving ... -
Dye-based chromoendoscopy following polypectomy reduces incomplete polyp resection.
(2020)Background and study aims: The completeness of a polyp resection is an important determinant of quality in colonoscopy, and may reduce incidence of interval cancers. Incomplete resection rates (IRR) vary widely and range ... -
Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers.
(2014)Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. Changes leading to specific ... -
Dysfunction of attention switching networks in amyotrophic lateral sclerosis.
(2019)Objective: To localise and characterise changes in cognitive networks in Amyotrophic Lateral Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. Rationale: The MMN waveform has an increased average ... -
?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)Objectives: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. Methods: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with ... -
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy
(2019)Age-related macular degeneration (AMD) is the leading cause of central retinal vision loss worldwide, with an estimated 1 in 10 people over the age of 55 showing early signs of the condition. There are currently no forms ... -
E-health empowers patients with ulcerative colitis: a randomised controlled trial of the web-guided 'Constant-care' approach.
(2010)Background: The natural history of ulcerative colitis requires continuous monitoring of medical treatment via frequent outpatient visits. The European health authorities' focus on e-health is increasing. Lack of easy access ...