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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/64039

Title: Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk
Author: MC MANUS, ROSS
Sponsor: 
Name Grant Number
505944

Author's Homepage: http://people.tcd.ie/rmcmanus
Keywords: Clinical medicine
Metabolic syndrome
cardiovascular risk factors
Smoking
Obesity
Issue Date: 2012
Citation: Catherine M Phillips, Emmanuelle Kesse-Guyot, Namanjeet Ahluwalia, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells, Helen M Roche, Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk, Atherosclerosis, 220, 2, 2012, 513-519
Series/Report no.: Atherosclerosis
220
2
Abstract: Objective: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel cardiometabolic risk factor. Whether dietary fat intake modulates MetS risk conferred by elevated C3 concentrations is unknown. Our objective is to investigate the relationship between C3 concentrations and risk of the MetS and its phenotypes, and to further examine whether dietary fat intake modulates these relationships. Methods: Biochemical, dietary and lifestyle measurements were determined in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). Results: Elevated C3 concentrations (> median) were associated with increased risk of impaired insulin sensitivity [OR 1.78, CI 1.34-2.36, P < 0.0001], insulin resistance [OR 1.73, CI 1.31-2.89, P = 0.0001], abdominal obesity [OR 2.15, CI 1.43-3.24, P = 0.0002] and low HDL cholesterol [OR 1.40, CI 1.05-1.86, P = 0.02] compared to low C3 concentrations. Increased MetS risk conferred by elevated C3 concentrations [OR 3.11, 95% CI 2.52-3.82, P < 0.0001] was further accentuated among high dietary fat consumers [OR 4.80, 95% CI 2.77-8.33, P < 0.0001] (particularly of saturated [OR 4.05, 95% CI 2.33-7.05, P < 0.0001] and monounsaturated fat [OR 4.48, 95% CI 2.62-7.56, P < 0.0001]), and smokers [OR 3.83, 95% CI 2.12-6.94, P < 0.0001], however this effect was abolished in abdominally lean individuals [OR 1.46, 95% CI 0.69-3.14, P = 0.33]. Conclusions: Dietary fat (intake and composition), abdominal obesity and smoking modulate the relationship between elevated plasma C3 concentrations and MetS risk.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/64039
Appears in Collections:Clinical Medicine (Scholarly Publications)

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