Browsing School of Chemistry by Sponsor "Higher Education Authority (HEA)"
Now showing items 1-20 of 21
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3-Urea-1,8-naphthalimides are good chemosensors: a highly selective dual colorimetric and fluorescent ICT based anion sensor for fluoride
(2011)he 1,8-naphthalimide sensor 1 was developed as a colorimetric and fluorescent sensor for anions. Being the first example of such anion sensors, where the 3-position of the naphthalimide ring is used to incorporate the anion ... -
Cation-π interactions: complexes of Guanidinium and simple aromatic systems
(2011)We have theoretically studied, in gas phase and using PCM-water solvation, the complexes established by the biologically relevant guanidinium cation and simple aromatic systems (benzene, naphthalene and pyridine). In gas ... -
Cell Proliferation Tracking Using Graphene Sensor Arrays
(2012)The development of a novel label-free graphene sensor array is presented. Detection is based on modification of graphene FET devices and specifically monitoring the change in composition of the nutritive components in ... -
Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones
(2010)A remarkably concise, chromatography-free route to the parent compound of the paullone family of cyclin-dependent kinase (CDK) inhibitors is reported. A similar strategy allowed the synthesis of the hitherto missing ... -
Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is an anti-cancer treatment method which uses the combined effect of a photosensitizing drug, light, and oxygen to cause selective damage to target tissue. The second generation photosensitizer ... -
Effect of external magnetic fields on electron transfer and ion pairing dynamics at ferrocenyl alkane thiol SAM/solution interfaces
(2010)The redox behaviour of ferrocene alkane thiol self assembled monolayer modified electrodes in contact with aqueous perchlorate solutions both in the absence of and in the presence of an external magnetic field is examined ... -
Folic acid modified gelatine coated quantum dots as potential reagents for in vitro cancer diagnostics.
(2011)BACKGROUND: Gelatine coating was previously shown to effectively reduce the cytotoxicity of CdTe Quantum Dots (QDs) which was a first step towards utilising them for biomedical applications. To be useful they also need ... -
Generation and Reactivity of Late Transition Metal Hydr(oxo) Complexes Supported by Tripodal Carboxamidate Ligand
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Metal oxo complexes (M=O) are important mediators of oxidative transformations in biological systems.1 Their high reactivity and transient nature have limited their study, with only a handful of well characterized oxo ... -
Magnetic field effects in ferrocenealkane thiol self assembled monolayer modified electrodes
(2010)The redox behaviour of well characterized ferrocene alkane thiol self assembled monolayer modified electrodes in contact with aqueous perchlorate solutions both in the absence of and in the presence of an external magnetic ... -
NMR studies into colloidal stability and magnetic order in fatty acid stabilised aqueous magnetic fluids
(2010)We report the physico-chemical characterisation of fatty acid stabilised aqueous magnetic fluids, which are ideal systems for studying the influence of nanoparticle aggregation on the emergent magnetic resonance properties ... -
On the Synthesis and Utilization of geminal-Dimethyl Hydroporphyrins and Tetraphenylethylenes in Photodynamic Therapy
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Chapter 1 introduces the main concepts of this thesis: photodynamic therapy (PDT), chlorins and photosensitizer arrays. In the case of PDT multiple topics are discussed, namely, the qualities of an ideal photosensitizer, ... -
One-step double reduction of aryl nitro and carbonyl groups using hydrazine
(2011)Single-step reduction of aryl nitro and carbonyl groups to the corresponding synthetically useful alkyl-anilines occurs with excellent yields by treatment with hydrazine and a base in a solvent-free reaction. The method ... -
Pyridin-2-yl Guanidine Derivatives: Conformational Control Induced by Intramolecular Hydrogen-Bonding Interactions.
(2011)The synthesis and conformational analysis of a series of pyridin-2-yl guanidine derivatives using NMR, X-ray crystallography and B3LYP/6-31+G** theoretical studies are reported. A remarkable difference was observed in ... -
Pyrrole-based Photosensitisers for Photomedicine. Synthesis, Photophysical and Photobiological Evaluation of Chlorins and Dipyrrin Complexes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is a light activated therapy which involves a drug-photosensitiser (PS), light, and molecular oxygen. First, the PS is administered via a systemic or topical route and then it accumulates in the ... -
Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation
(2011)The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and ... -
Self-assembled rows of Ni porphyrin dimers on the Ag(111) surface
(2010)The growth and ordering of 5-(10,15,20-triphenylporphyrinatonickel(II))dimer (NiTPP-dimer) molecules on the Ag(111) surface have been investigated using scanning tunnelling microscopy/spectroscopy (STM/STS) and low-energy ... -
Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA.
(2010)[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent ? and ? enantiomers. The DNA-binding interactions of each of the racemic complexes were ... -
Synthesis and analysis of Nile Red functionalised Ru(II) and Ir(III) photosensitisers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Nile Red (9-(diethylamino)-5H-benzo[a]phenoxazin-5-one) is a common organic dye that exhibits strong absorption of visible light, and is highly fluorescent. Despite these properties, examples of transition metal complexes ... -
Synthesis, characterisation and biological evaluation of N-(ferrocenyl)naphthoyl amino acid esters as anticancer agents
(2010)A series of N-(ferrocenyl)naphthoyl amino acid esters 5?18 has been prepared by coupling ferrocenyl naphthoic acids 3?4 to ?-amino acids and linear amino acids in the presence of N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide ... -
Synthesis, structural characterisation and luminescent anion sensing studies of a Ru(II)polypyridyl complex featuring an aryl urea derivatised 2,2'-bpy auxiliary ligand
(2012)The inclusion of a urea functionality into the coordination sphere of a Ru(II)-polypyridyl complex (Ru?L1) resulted in a system that can function as an effective long wavelength emissive fluorescent anion sensor. The MLCT ...