Browsing Histopathology & Morbid Anatomy (Theses and Dissertations) by Title

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Now showing items 37-44 of 44

  • Regulation of cancer stem cell differentiation by genes and microRNAs 

    Vencken, Sebastian (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)
    Since the discovery of a stem cell phenotype in cancer, specific tumour cells with this phenotype, often called cancer stem cells (CSCs), are now widely accepted as the progenitors of oncogenesis, proliferation, treatment ...

  • Targeting the prostate cancer metabolome with novel trojan horse compounds. 

    Bogue Edgerton, Laura Isobel (Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023)
    Prostate cancer (PCa) is the second most common cancer diagnosed in males worldwide, and the incidence of this disease is predicted to double globally by 2030. In Ireland, PCa accounts for nearly 16% of all invasive cancers ...

  • The expression and function of miRNAs in thyroid neoplasia 

    Aherne, Sinéad (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)
    Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer deaths each year. Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive clinical and ...

  • The p16INK4A pathway in cervical cancer 

    Kehoe, Louise (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)
    The p16INK4A protein has been proposed as a biomarker in cervical cancer and pre-cancer. p16INK4A over expression is in contrast to that seen in other cancers, where locus deletion or mutation is the norm. p16INK4A is ...

  • The role of activated RET in papillary tumour morphogenesis 

    Flavin, Richard (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011)
    RET/PTC rearrangements are initiating events in the development of a significant proportion of papillary thyroid carcinomas. Activated RET/PTC mutations are thought to be restricted to thyroid disease, but in this study ...

  • The role of MyD88 in embryonal carcinoma stem cells 

    Sulaiman, Gomaa M. A. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)
    Tumour-initiating cells are known to share some properties with stem cells. These so called 'Cancer Stem Cells' (CSCs) are highly tumourigenic in the undifferentiated state, a property that is lost upon CSC differentiation. ...

  • The silencing of HPV16 Oncogenes using E6siRNAs 

    Soyingbe, Itunu Senami O. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2014)
    Cervical cancer is the fourth most common cancer worldwide and remains a rising cause of cancer deaths amongst women worldwide, particularly in low to mid-income countries. High risk HPV is the main etiological factor in ...

  • The use of nanotechnology for treatment of multidrug resistant ovarian cancer cells 

    SAED, MELAD ELHADI (Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2019)
    The traditional ovarian cancer treatment includes a combination of surgery and chemotherapy. However, the prognosis for ovarian cancer following treatment is very poor in the majority of ovarian cancer patients, especially ...