The silencing of HPV16 Oncogenes using E6siRNAs
Citation:Itunu Senami O. Soyingbe, 'The silencing of HPV16 Oncogenes using E6siRNAs', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2014, pp 312
Soyingbe TCD THESIS 10473 The silencing.pdf (PDF) 169.4Mb
Cervical cancer is the fourth most common cancer worldwide and remains a rising cause of cancer deaths amongst women worldwide, particularly in low to mid-income countries. High risk HPV is the main etiological factor in cervical carcinogenesis. The overexpression of high risk HPV E6 and E7 due to viral genome integration and loss of high risk E2 is the key factor in this disease progression. These oncogenes subvert cellular tumour suppressor genes (p53 and unphosphorylated pRB) and create a neoplastic environment that facilitates increased cellular alterations that promote malignancy.
Author: Soyingbe, Itunu Senami O.
Publisher:Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy
Note:TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: firstname.lastname@example.org
Type of material:thesis
Availability:Full text available