The role of MyD88 in embryonal carcinoma stem cells
Citation:Gomaa M. A. Sulaiman, 'The role of MyD88 in embryonal carcinoma stem cells', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015, pp 177
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Tumour-initiating cells are known to share some properties with stem cells. These so called 'Cancer Stem Cells' (CSCs) are highly tumourigenic in the undifferentiated state, a property that is lost upon CSC differentiation. For many years, our group has studied CSC differentiation in a nullipotent embryonal carcinoma CSC cell line (2102Ep), which can resist differentiation to produce highly-aggressive tumours. Previous work in the lab highlighted a potential role for Toll-Like Receptor (TLR) Signaling mediator protein Myeloid Differentiation Response Gene 88 (MyD88) in the mechanism through which 2102Ep cells resist differentiation.
Author: Sulaiman, Gomaa M. A.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy
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Type of material:thesis
Availability:Full text available