Browsing Biochemistry (Scholarly Publications) by Subject "Genotoxic stress"
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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
(2008)The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose ...