Browsing Biochemistry (Scholarly Publications) by Sponsor "European Commission"
Now showing items 1-9 of 9
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Crystallizing Transmembrane Peptides in Lipidic Mesophases
(2010)Structure determination of membrane proteins by crystallographic means has been facilitated by crystallization in lipidic mesophases. It has been suggested, however, that this so-called in meso method, as originally ... -
Depletion of glutathione does not affect electron transport chain complex activities in brain mitochondria: Implications for Parkinsons's disease and postmortem studies
(2011)Glutathione is an important antioxidant in the brain that appears to be decreased, in conjunction with mitochondrial complex I activity, in Parkinson?s disease patients. In postmortem analysis, measurement of glutathione ... -
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents
(2018)We developed a Jocic-type protocol for the construction of the pyrrolonaphthoxazepine (PNOX) core. After an initial investigation based on the isolation of a trichloromethyl carbinol derivative, we shifted our attention ... -
Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes
(2011)The lipidic cubic mesophase has been used to crystallize important membrane proteins for high-resolution structure determination. To date, however, no integral membrane enzymes have yielded to this method, the in meso. For ... -
The role of UCP 1 in the production of reactive oxygen species by mitochondria isolated from brown adipose tissue
(2010)We provide evidence that ablation or inhibition of, uncoupling protein 1 increases the rate of reactive oxygen containing species production by mitochondria from brown adipose tissue, no matter what electron transport chain ...