Browsing Biochemistry (Scholarly Publications) by Author "Sheedy, Frederick"
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A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
Keane, Joseph; O'Sullivan, Mary; O'Neill, Luke; Lavelle, Edward; Corr, Sinead; Palsson Mcdermott, Eva; Sheedy, Frederick; Ni Cheallaigh, Cliona; Gleeson, Laura; Munoz-Wolf, Natalia (2016)Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those ... -
Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication.
Keane, Joseph; O'Sullivan, Mary; O'Neill, Luke; Palsson Mcdermott, Eva; Sheedy, Frederick; Gleeson, Laura (2016)Recent advances in immunometabolism link metabolic changes in stimulated macrophages to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium tuberculosis. To investigate this pathway in ... -
Mycobacterium tuberculosis Limits Host Glycolysis and IL-1? by Restriction of PFK-M via MicroRNA-21
Sheedy, Frederick; Keane, Joseph; Corr, Sinead; Lavelle, Edward; Johnston, Daniel; Gleeson, Laura; Munoz-Wolf, Natalia (2020)Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we ...