Browsing Biochemistry (Scholarly Publications) by Author "SCOTT, JOHN MARTIN"
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Cobalamin, folic acid, and homocysteine
SCOTT, JOHN MARTIN (John Wiley, 2009)Cobalamin deficiency can lead to several adverse health consequences: folate trapping in the methylation cycle and subsequent impaired DNA biosynthesis; pernicious anemia hematologically, similar to that caused by folate ... -
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2009)Polymorphisms in folate-related genes have emerged as important risk factors in a range of diseases including neural tube defects (NTDs), cancer, and coronary artery disease (CAD). Having previously identified a polymorphism ... -
Facts and recommendations about total homocysteine determinations: an expert opinion
MCPARTLIN, JOSEPH; SCOTT, JOHN MARTIN (American Association for Clinical Chemistry, 2004)Background: Measurement of plasma total homocysteine has become common as new methods have been introduced. A wide range of disorders are associated with increased concentrations of total homocysteine. The purpose of this ... -
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements
MCPARTLIN, JOSEPH; SCOTT, JOHN MARTIN (American Society for Clinical Nutrition, 2002)Background: Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5) supplies the folate needed for the metabolism of homocysteine. A reduction in MTHFR activity, as occurs in the homozygous state for the 677CT (so-called ... -
Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?
SCOTT, JOHN MARTIN (BioMed Central, 2009)BACKGROUND: Ireland is an example of a country that has extensive voluntary fortification with folic acid. After a public consultation process, in 2006, the Food Safety Authority in Ireland FSAI 1 recommended mandatory ... -
Personalised nutrition Genetic variation and disease risk: new advances
SCOTT, JOHN MARTIN (Cambridge University Press, 2009)Variations in human DNA, most frequently single-nucleotide polymorphisms (SNPs), can have functional consequences ranging from severe to none. Variations in outcome (phenotype) can be compared, from cystic fibrosis through ... -
The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study
MCPARTLIN, JOSEPH; SCOTT, JOHN MARTIN (American Society for Clinical Nutrition, 2002)Background: Fasting plasma total homocysteine (tHcy) decreases during pregnancy. Previous reports suggested that this is due to folic acid supplementation, hemodilution, or a decrease in albumin. However, these hypotheses ... -
The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women.
SCOTT, JOHN MARTIN (Wiley-Blackwell, 2009)Low folate status may be a consequence of suboptimal intake, transport or cellular utilization of folate and, together with elevated homocysteine, is a recognized risk factor or marker for several human pathologies. As ... -
Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation
SCOTT, JOHN MARTIN (American Association for Clinical Chemistry, 2002)Background: Vitamin B2 exists in blood as riboflavin and its cofactors, flavin mononucleotide (FMN) and FAD. The erythrocyte glutathione reductase activation coefficient (EGRAC) has traditionally been used to assess vitamin ... -
Screening for vitamin B-12 and folate deficiency in older persons
SCOTT, JOHN MARTIN (American Society for Clinical Nutrition, 2003)Background: Vitamin B-12 deficiency is usually accompanied by elevated concentrations of serum total homocysteine (tHcy) and methylmalonic acid (MMA). Folate deficiency also results in elevated tHcy. Measurement of these ...