Browsing Biochemistry (Scholarly Publications) by Author "Relitti, Nicola"
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A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents
Zisterer, Daniela; Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania (2018)We developed a Jocic-type protocol for the construction of the pyrrolonaphthoxazepine (PNOX) core. After an initial investigation based on the isolation of a trichloromethyl carbinol derivative, we shifted our attention ... -
Raising the bar in anticancer therapy:recent advances in, and perspectives on, telomerase inhibitors
Zisterer, Daniela; Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe (2019)Telomerase is a ribonucleic reverse transcriptase enzyme that uses an integral RNA component as a template to add tandem telomeric DNA repeats, TTAGGG, at the 3′ end of the chromosomes. 85–90% of human tumors and their ...