Browsing Biochemistry (Scholarly Publications) by Author "O'Neill, Luke"
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Author Correction: A guiding map for inflammation (Nature Immunology, (2017), 18, 8, (826-831), 10.1038/ni.3790)
Mills, Kingston; O'Neill, Luke (2021) -
Bridging the gap – a new role for STAT3 in TLR4-mediated metabolic reprogramming
O'Neill, Luke (2021)In this article, we discuss a new study from the laboratory of Ashley Mansell that successfully links innate immune receptor signaling to metabolic changes in macrophages, establishing for the first time an uninterrupted ... -
Caspase-11 promotes allergic airway inflammation
Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J.; Wygrecka, Małgorzata (2020)Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ... -
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future
O'Neill, Luke (2022)A plethora of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic tests are available, each with different performance specifications, detection methods, and targets. This narrative review aims to ... -
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
Keane, Joseph; O'Sullivan, Mary; O'Neill, Luke; Lavelle, Edward; Corr, Sinead; Palsson Mcdermott, Eva; Sheedy, Frederick; Ni Cheallaigh, Cliona; Gleeson, Laura; Munoz-Wolf, Natalia (2016)Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those ... -
Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.
O'Neill, Luke; Doyle, Sarah; Canavan, Mary (2013)Polyunsaturated fatty acids (PUFA) can modulate the immune response, however the mechanism by which they exert this effect remains unclear. Previous studies have clearly demonstrated that the cis-9, trans-11 isomer of ... -
Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication.
Keane, Joseph; O'Sullivan, Mary; O'Neill, Luke; Palsson Mcdermott, Eva; Sheedy, Frederick; Gleeson, Laura (2016)Recent advances in immunometabolism link metabolic changes in stimulated macrophages to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium tuberculosis. To investigate this pathway in ... -
Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production
O'Neill, Luke (2019)Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the ... -
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
O'Neill, Luke; Baardman, Jeroen; Verberk, Sanne G.S.; Prange, Koen H.M.; van Weeghel, Michel; van der Velden, Saskia; Ryan, Dylan G.; Wüst, Rob C.I.; Neele, Annette; Speijer, Dave; Denis, Simone W.; Witte, Maarten E.; Houtkooper, Riekelt H.; Knatko, Elena V.; Dinkova-Kostova, Albena T.; Lutgens, Esther; de Winther, Menno P.J.; Van den Bossche, Jan (2018)Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of ... -
Evidence against a role for NLRP3-driven islet inflammation in db/db mice
O'Neill, Luke; Kammoun, H.L.; Allen, T.L.; Henstridge, D.C.; Barre, S.; Coll, R.C.; Lancaster, G.I.; Cron, L.; Reibe, S.; Chan, J.Y.; Bensellam, M.; Laybutt, D.R.; Butler, M.S.; Robertson, A.A.B.; Cooper, M.A.; Febbraio, M.A. (2018)Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
Hooftman, Alexander; O'Neill, Luke (2019)The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and ... -
Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology
O'Neill, Luke (2019)Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for ... -
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network
Bowie, Andrew; O'Neill, Luke (2020)The past century has witnessed major advances in the control of many infectious diseases, yet outbreaks and epidemics caused by (re-) emerging RNA viruses continue to pose a global threat to human health. As illustrated ... -
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Hooftman, Alexander; O'Neill, Luke (2020)The Krebs cycle-derived metabolite itaconate is highly upregulated in inflammatory macrophages and exerts immunomodulatory effects through cysteine modifications on target proteins. The NLRP3 inflammasome, which cleaves ... -
Improved performance of near infrared excitation Raman spectroscopy using reflective thin-film gold on glass substrates for cytology samples
O'Neill, Luke (2019)Confocal near-infrared Raman spectroscopy has been shown to have applications in the area of clinical biology. A source wavelength in the near infrared is preferred over visible wavelengths for inspecting biological samples ... -
Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice.
O'Toole, Sharon; O'Neill, Luke; Martin, Cara (2020)Influenza A virus (IAV) infection during pregnancy causes severe maternal and perinatal complications, despite a lack of vertical transmission of IAV across the placenta. Here, we demonstrate a significant alteration in ... -
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
Mills, Kingston; Sutton, Caroline; O'Neill, Luke; Finlay, Conor (2017) -
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
Mc Gettrick-Dillon, Anne; O'Neill, Luke (Springer Nature, 2023-03-08)Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory ... -
Malonylation of GAPDH is an inflammatory signal in macrophages
O'Neill, Luke; Kelly, Vincent; Palsson Mcdermott, Eva (2019)Macrophages undergo metabolic changes during activation that are coupled to functional responses. The gram negative bacterial product lipopolysaccharide (LPS) is especially potent at driving metabolic reprogramming, enhancing ... -
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
O'Neill, Luke (2022)To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH ...