Browsing Biochemistry (Scholarly Publications) by Author "O'NEILL, LUKE ANTHONY JOHN"
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2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC)
O'NEILL, LUKE ANTHONY JOHN (Portland Press, 1997)The metal chelator and anti-oxidant pyrollidine dithiocarbamate (PDTC) has been used extensively in studies implicating reactive oxygen intermediates in the activation of nuclear factor kappa B (NF kappa B). In agreement ... -
Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures.
O'NEILL, LUKE ANTHONY JOHN (2011)Introduction: The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells. Methods: RA synovial tissue biopsies, obtained under direct visualization ... -
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
O'NEILL, LUKE ANTHONY JOHN (American Society for Biochemistry and Molecular Biology, 2003)In this study we have identified members of the Toll-like receptor (TLR) family (namely, TLRs 4, 6, 8, and 9) as proteins to which the intracellular protein tyrosine kinase, Bruton's tyrosine kinase (Btk), binds. Detailed ... -
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS
DOYLE, SARAH LOUISE; O'NEILL, LUKE ANTHONY JOHN (2005)Bruton's tyrosine kinase (Btk) has recently been shown to participate in the induction of nuclear factor ?B (NF?B)-dependent gene expression by the lipopolysaccharide (LPS) receptor Toll-like receptor-4 (TLR4). In this ... -
Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 1995)Tumor necrosis factor (TNF) is a pleiotropic cytokine which has both cytotoxic and proliferative effects. HuT 78, a T-cell line derived from a Sezary lymphoma, is resistant to the cytotoxic effects of TNF, suggesting that ... -
Ceramide activates NFkappaB by inducing the processing of p105
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 1998)The role of ceramide as a second messenger in tumor necrosis factor (TNF)-mediated signal transduction has been much debated. It is supported by recent reports describing an expanding number of potential targets for this ... -
Characterization of CD44 induction by IL-1: a critical role for Egr-1
O'NEILL, LUKE ANTHONY JOHN (The American Association of Immunologists, 1999)he adhesion molecule CD44 is a multifunctional, ubiquitously expressed glycoprotein that participates in the process of leukocyte recruitment to sites of inflammation and to their migration through lymphatic tissues. In ... -
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2004)The Toll/interleukin-1 receptor (TIR) domain is conserved in the intracellular regions of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) as well as in several cytoplasmic adapter molecules. This domain has ... -
Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 1997)The anthracycline antibiotic, daunorubicin, can induce programmed cell death (apoptosis) in cells. Recent work suggests that this event is mediated by ceramide via enhanced ceramide synthase activity. Since the generation ... -
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
O'NEILL, LUKE ANTHONY JOHN (PLoS, 2007)The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative ... -
Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1
O'NEILL, LUKE ANTHONY JOHN; PALSSON, EVA (The American Society for Biochemistry and Molecular Biology, 2000)We have found that lethal toxin from Clostridium sordellii, which specifically inactivates the low molecular weight G proteins Ras, Rap, and Rac, inhibits the activation of p38 mitogen-activated protein kinase (MAPK) by ... -
The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3
O'NEILL, LUKE ANTHONY JOHN; TANNAHILL, GILLIAN (Elsevier, 2011)While it has long been suspected that inflammation participates in the pathogenesis of metabolic disorders such as the insulin resistance that occurs in type 2 diabetes, recent work suggests that this is not the only ... -
Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect
O'NEILL, LUKE ANTHONY JOHN (British Pharmacological Society, 1987)Feverfew has been used since antiquity to treat inflammatory conditions. Extracts of the herb were found to inhibit mitogen-induced tritiated thymidine ([3H]-TdR) uptake by human peripheral blood mononuclear cells (PBMC), ... -
A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis
O'NEILL, LUKE ANTHONY JOHN; DUNNE, AISLING (2007)Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens1, 2, 3. The adaptor protein Mal (also known as TIRAP), encoded ... -
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like
O'NEILL, LUKE ANTHONY JOHN; CARPENTER, SUSAN; PALSSON MCDERMOTT, EVA (2008)Phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) is essential for the induction of promoters which contain the interferon-stimulated response element (ISRE). IRF3 can be activated by Toll-like ... -
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
O'NEILL, LUKE ANTHONY JOHN (American Society for Biochemistry and Molecular Biology, 2004)Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with ... -
IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2006)The members of the NF-?B transcription factor family are key regulators of gene expression in the immune response. Different combinations of NF-?B subunits not only diverge in timing to induce transcription but also recognize ... -
Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2003)Interferon regulatory factor (IRF) 3 is a transcription factor that binds the interferon-sensitive response element (ISRE) and is activated by Toll-like receptor 3 (TLR3) and TLR4. We have found that a dominant negative ... -
Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 1992)It is not known whether one or both of the interleukin 1 (IL1) receptors mediates the induction of the DNA-binding protein NF-kappa B. Nuclear extracts of the murine lines EL4.NOB.1 and 70Z/3, which bear the type I (80 ... -
Interleukin-1 activates transcription factor NF kappa B in glial cells
O'NEILL, LUKE ANTHONY JOHN (Portland Press, 1993)Recombinant human interleukin-1 (IL-1) alpha and beta were found to activate a latent cytosolic form of the transcription factor NF kappa B in rat C6 glioma. IL-1 beta was 10 times more potent than IL-1 alpha for this ...