Browsing Biochemistry (Scholarly Publications) by Author "O'BOYLE, NIAMH"
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Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA; WILLIAMS, DAVID CLIVE; KNOX, ANDREW; LLOYD, DAVID G; O'BOYLE, NIAMH (Elsevier, 2011)Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical ... -
Synthesis, Biochemical and Molecular Modelling Studies of Antiproliferative Azetidinones causing Microtubule Disruption and Mitotic Catastrophe
MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA; KEELY, NIALL O.; MC CABE, THOMAS; GREENE, LISA; KNOX, ANDREW; LLOYD, DAVID G; O'BOYLE, NIAMH (Elsevier, 2011)The structure-activity relationships of antiproliferative ?-lactams, focusing on modifications at the 4-position of the ?-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the Staudinger ...