Browsing Biochemistry (Scholarly Publications) by Author "FALLON, PADRAIC"
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Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylceramide
O'FARRELLY, CLIONA; O'REILLY, VINCENT; Dunne, Margaret; AMU, SYLVIE; FALLON, PADRAIC; DOHERTY, DEREK; ZENG, SHIJUAN GRACE (2011)Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid ?-galactosylceramide (?-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. ... -
MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C
CORR, SINEAD; O'NEILL, LUKE; PALSSON, EVA; FALLON, PADRAIC (2014)The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ... -
A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins
O'NEILL, LUKE; AMU, SYLVIE; MCCOY, CLAIRE; MORTON, CHARLES; ROGERS, THOMAS; FALLON, PADRAIC; KELLEHER, DERMOT (2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ...