Browsing Biochemistry (Scholarly Publications) by Author "Carty, Michael"
Now showing items 1-7 of 7
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CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages
Carty, Michael; Kelly, Vincent; Bowie, Andrew; Hokamp, Karsten (2021)SARM1 is a toll/interleukin-1 receptor -domain containing protein, with roles proposed in both innate immunity and neuronal degeneration. Murine SARM1 has been reported to regulate the transcription of chemokines in both ... -
Detection of Viral Infections by Innate Immunity
Carty, Michael; Bowie, Andrew (2021)Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to viral ... -
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Mills, Kingston; Carty, Michael; Ni Cheallaigh, Cliona (2023)Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading ... -
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
Carty, Michael (2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.
Bowie, Andrew; Carty, Michael (2014)The four Toll/IL-1R domain-containing adaptor proteins MyD88, MAL, TRIF, and TRAM are well established as essential mediators of TLR signaling and gene induction following microbial detection. In contrast, the function of ...