Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 364-383 of 725
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Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths.
(2013)We previously demonstrated that uncoupling protein 1 activity, as measured in isolated brown adipose tissue mitochondria (and as a native protein reconstituted into liposome membranes), was not activated by the non-flippable ... -
Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects
(2009)Molloy AM, Quadros EV, Sequeira JM, Troendle JF, Scott JM, Kirke PN, Mills JL. `Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects? in New England Journal of Medicine, 361, (2), 2009, pp 152-160 -
Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
(Elsevier, 2011)Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical ... -
Lead identification of conformationally restricted ?-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects
(Elsevier, 2010)The synthesis and study of the structure-activity relationships of a series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (?-lactam) ring system in place of the usual ... -
Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes
(2011)The lipidic cubic mesophase has been used to crystallize important membrane proteins for high-resolution structure determination. To date, however, no integral membrane enzymes have yielded to this method, the in meso. For ... -
Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes.
(2011)The lipidic cubic mesophase has been used to crystallize important membrane proteins for high-resolution structure determination. To date, however, no integral membrane enzymes have yielded to this method, the in meso. For ... -
The lipid cubic phase or in meso method for crystallizing proteins. Bushings for better manual dispensing
(2014)The lipid cubic phase or in meso method can be used to set up crystallization trials of soluble and membrane proteins. The cubic phase is noted for being a sticky and viscous mesophase. Dispensing the protein-laden ... -
Lipid-sugar interaction: Relevance to anhydrous biology
(American Society of Plant Biologists, 1988)The ability of seeds and other anhydrous plant forms to survive the withdrawal of water must involve a mechanism for protecting the integrity of cellular membranes. Evidence from animal systems implicates sugars as protective ... -
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
(2014)Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane ... -
Liver immunology and its role in inflammation and homeostasis
(2016)The human liver is usually perceived as a non-immunological organ engaged primarily in metabolic, nutrient storage and detoxification activities. However, we now know that the healthy liver is also a site of complex ... -
LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells
(Wiley-Blackwell, 2010)The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the ... -
A long noncoding RNA mediates both activation and repression of immune response genes.
(2013)An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional ... -
Long term detection and quantification of SARS-CoV-2 RNA in wastewater in Bahrain
(2022)Wastewater-based epidemiology is a corroborated environmental surveillance tool in the global fight against SARS-CoV-2. The analysis of wastewater for detection of SARS-CoV-2 RNA may assist policymakers to survey a specific ... -
Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I deficient mice.
(2013)ABSTRACT Emerging evidence has demonstrated that saturated fatty acids prime pro-IL-1β production and inflammasome-mediated IL-1β activation is critical in obesity-associated insulin resistance (IR). Nonetheless, IL-1 ... -
LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production.
(2014)Programmed cell death protein 4 (PDCD4) is a tumor suppressor and has also been shown to suppress production of the immunomodulatory cytokine IL-10. The precise role of PDCD4 in IL-10 induction in macrophages is still not ... -
Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract.
(2013)Developing efficacious vaccines against enteric diseases is a global challenge that requires a better understanding of cellular recruitment dynamics at the mucosal surfaces. The current paradigm of T cell homing to the ... -
A lyotrope gradient method for liquid crystal temperature-composition-mesomorph diagram construction using time-resolved x-ray diffraction.
(1989)A new method for rapidly constructing isobaric temperature-composition-mesomorph (T-C) diagrams is described. The method involves establishing a lyotrope concentration gradient in a liquid crystal lengthwise in an x-ray ... -
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
(Springer Nature, 2023-03-08)Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory ...