Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 357-376 of 725
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Kinetics of the barotropic ripple (P beta')/lamellar liquid crystal (L alpha) phase transition in fully hydrated dimyristoylphosphatidylcholine (DMPC) monitored by time-resolved x-ray diffraction.
(1991)We present here the first study of the use of a pressure-jump to induce the ripple (P,.)/lamellar liquid crystal (Lj phase transition in fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). The transition ... -
Kinetics of the lamellar and hexagonal phase transitions in phosphatidylethanolamine. Time-resolved x-ray diffraction study using a microwave-induced temperature jump.
(1990)The kinetics of the thermotropic lamellar gel (L)/lamellar liquid crystal (La) and La/inverted hexagonal (H,,) phase transitions in fully hydrated dihexadecylphosphatidylethanolamine (DHPE) have been studied. Measurements ... -
Kinetics of the main phase transition of hydrated lecithin monitored by real-time X-ray diffraction.
(Elsevier, 1984)A method is described for observing and recording in real-time x-ray diffraction from an unoriented hydrated membrane lipid, dipalmitoylphosphatidylcholine (DPPC), through its thermotropic gel/liquid crystal phase transition. ... -
Kinetics of the premelting (L beta'-P beta') and main transition (P beta'-L alpha) in hydrated dipalmitoylphosphatidylcholine. A time-resolved x-ray diffraction study using microwave-induced temperature-jumps.
(1990)The dynamics and mechanism of the premelting (L beta'-P beta') and main transitions (P beta'-L alpha) in fully hydrated dipalmitoylphosphatidylcholine were examined by low-angle time-resolved x-ray diffraction (TRXRD) using ... -
Korean Immigrant Experiences in America and in Ireland: Breaking the Vicious Circle of Ethnic Patterns
(Trinity College Dublin and Trauben Edizioni, 2014) -
Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths.
(2013)We previously demonstrated that uncoupling protein 1 activity, as measured in isolated brown adipose tissue mitochondria (and as a native protein reconstituted into liposome membranes), was not activated by the non-flippable ... -
Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects
(2009)Molloy AM, Quadros EV, Sequeira JM, Troendle JF, Scott JM, Kirke PN, Mills JL. `Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects? in New England Journal of Medicine, 361, (2), 2009, pp 152-160 -
Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
(Elsevier, 2011)Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical ... -
Lead identification of conformationally restricted ?-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects
(Elsevier, 2010)The synthesis and study of the structure-activity relationships of a series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (?-lactam) ring system in place of the usual ... -
Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes
(2011)The lipidic cubic mesophase has been used to crystallize important membrane proteins for high-resolution structure determination. To date, however, no integral membrane enzymes have yielded to this method, the in meso. For ... -
Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes.
(2011)The lipidic cubic mesophase has been used to crystallize important membrane proteins for high-resolution structure determination. To date, however, no integral membrane enzymes have yielded to this method, the in meso. For ... -
The lipid cubic phase or in meso method for crystallizing proteins. Bushings for better manual dispensing
(2014)The lipid cubic phase or in meso method can be used to set up crystallization trials of soluble and membrane proteins. The cubic phase is noted for being a sticky and viscous mesophase. Dispensing the protein-laden ... -
Lipid-sugar interaction: Relevance to anhydrous biology
(American Society of Plant Biologists, 1988)The ability of seeds and other anhydrous plant forms to survive the withdrawal of water must involve a mechanism for protecting the integrity of cellular membranes. Evidence from animal systems implicates sugars as protective ... -
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
(2014)Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane ... -
Liver immunology and its role in inflammation and homeostasis
(2016)The human liver is usually perceived as a non-immunological organ engaged primarily in metabolic, nutrient storage and detoxification activities. However, we now know that the healthy liver is also a site of complex ... -
LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells
(Wiley-Blackwell, 2010)The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the ... -
A long noncoding RNA mediates both activation and repression of immune response genes.
(2013)An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional ...