Browsing Physiology (Scholarly Publications) by Author "MILLS, KINGSTON"
Now showing items 1-8 of 8
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Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
LYNCH, MARINA; MILLS, KINGSTON (2011)The blockade of adenosine A2A receptors (A2AR) affords a robust neuroprotection in different noxious brain conditions. However, the mechanisms underlying this general neuroprotection are unknown. One possible mechanism ... -
CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.
LYNCH, MARINA ANNETTA; MILLS, KINGSTON (Society for Neuroscience, 2007)Deficits in cognitive function are associated with neuroinflammatory changes, typified by activation of glial cells and an alteration of the pro- and anti-inflammatory cytokine balance in the brain. Although there is ... -
IFN-? Production by Amyloid ?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.
MILLS, KINGSTON; LYNCH, MARINA ANNETTA (2013)Alzheimer?s disease (AD) is characterized by the presence of amyloid-b (Ab)?containing plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes, typified by activated microglia, particularly ... -
Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
LYNCH, MARINA; MILLS, KINGSTON (2011)Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative diseases but the extent to which the immune system is involved in the pathogenesis of these diseases is unclear. The findings of several ... -
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
LYNCH, MARINA; O'NEILL, LUKE; MILLS, KINGSTON; FINUCANE, ORLA (2017) -
Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice.
MCMANUS, ROSS; LYNCH, MARINA; MILLS, KINGSTON (2014)Alzheimer?s disease (AD) is a progressive neurodegenerative disease characterized by deposits of amyloid-? and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease; however, ... -
Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus.
LYNCH, MARINA ANNETTA; MILLS, KINGSTON (The American Society for Biochemistry and Molecular Biology, 2005)It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory ... -
Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination
LYNCH, MARINA ANNETTA; MILLS, KINGSTON (American Society for Microbiology, 2001)Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children. ...