Browsing Physiology (Scholarly Publications) by Title
Now showing items 65-84 of 136
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How dependent is synaptic plasticity on microglial phenotype?
(2015)Microglia are particularly plastic cells which can be shifted from their resting state by numerous factors and adopt distinct phenotypes. The cells are multifunctional, though their main role is probably maintenance of ... -
Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity.
(2009)Background Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and ... -
Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory
(2013)Background Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like ... -
IFN-? Production by Amyloid ?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.
(2013)Alzheimer?s disease (AD) is characterized by the presence of amyloid-b (Ab)?containing plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes, typified by activated microglia, particularly ... -
Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
(2011)Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative diseases but the extent to which the immune system is involved in the pathogenesis of these diseases is unclear. The findings of several ... -
The impact of aging on the brain - risk, resilience and repair
(2012)This Brief Commentary describes a Special Issue that features a series of papers that provide new data on how aging and inflammation interact to affect behaviors that are regulated by the dialogue between the immune system ... -
The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
(2013)Neuroinflammatory changes are a characteristic of several, if not all, neurodegenerative diseases including Alzheimer?s disease (AD) and are typified by increased microglial activation. Microglia express several receptors ... -
Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased A? accumulation and microglial activation.
(2013)Background: Alzheimer?s Disease is characterized by progressive neuronal loss and cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women even when data are adjusted for age. Objective: ... -
Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes.
(2018)A defining pathophysiological hallmark of Alzheimer’s disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard, brittle structures scattered throughout ... -
Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise
(2019)We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with ... -
Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice
(2015)There is a wealth of evidence indicating that macrophages adopt distinct phenotypes when exposed to specific stimuli and, in the past few years, accumulating data suggest that microglia behave somewhat similarly. Therefore, ... -
Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation
(2019)The group I metabotropic glutamate (mGlu) receptor subtypes, mGlu1 and mGlu5, strongly regulate hippocampal synaptic plasticity. Both harbor PSD-95/discs-large/ZO-1 (PDZ) motifs at their extreme carboxyl terminals, which ... -
Internal models for bi-manual tasks
(2004)Co-ordinated bi-manual actions form the basis for many everyday motor skills. In this review, the internal model approach to the problem of bi-manual co-ordination is presented. Bi-manual coordinative tasks are often ... -
Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.
(2019)Among the changes that typify Alzheimer’s disease (AD) are neuroinflammation and microglial activation, amyloid deposition perhaps resulting from compromised microglial function and iron accumulation. Data from Genome Wide ... -
Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.
(2013)Increasing global birth rate, coupled with the aging population surviving into their eighth decade has lead 26 to increased incidence diseases, hitherto designated as rare. Brain related ischemia, at birth, or later in ... -
The kinematics of phonotactic steering in the cricket Gryllus bimaculatus
(2011)Female crickets, Gryllus bimaculatus, are attracted by the male calling song and approach singing males; a behaviour known as phonotaxis. Even tethered females walking on a trackball steer towards a computer-generated male ... -
Learning and decay of prediction in object manipulation.
(2000)Anticipating the consequences of our own actions is a fundamental component of normal sensorimotor control and is seen, for example, during the manipulation of objects. When one hand pulls on an object held in the other ... -
Levels of S100B are raised in female patients with schizophrenia.
(2013)Background The neurotrophic factor, S100B, is released primarily from astrocytes, with serum and CSF levels of S100B reported as altered in schizophrenia. However, many of these reports are contradictory. Here, serum ...
