The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
Citation:
Lynch MA, The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease., Immunology, 141, 3, 2013, 292-301Abstract:
Neuroinflammatory changes are a characteristic of several, if not all, neurodegenerative
diseases including Alzheimer?s disease (AD) and are typified by increased microglial
activation. Microglia express several receptors making them highly reactive and plastic
cells, and, at least in vitro, they adopt different phenotypes in a manner analogous to their
peripheral counterparts, macrophages. Microglia also express numerous cell surface
proteins enabling them to interact with cells and the evidence indicates that maintenance of
microglia in a quiescent state relies, at least to some extent, on an interaction with neurons
by means of specific ligand-receptor pairs for example CD200-CD200R. It is clear that
microglia also interact with T cells and recent evidence indicates that co-incubation of
microglia with Th1 cells markedly increase their activation
?
?
?
Under normal conditions, small
numbers of activated T cells gain entry to the brain and are involved in immune
surveillance but infiltration of significant numbers of T cells occurs in disease and
following injury. The consequences of T cell infiltration appear to depend on the
conditions, with descriptions of both neur
odestructive and neuroprotective effects in
animal models of different diseases. This review will discuss the modulatory effect of T
cells on microglia and impact of infiltration of T cells into the brain with a focus on AD
and will propose that infiltration of interferon (IFN)-
?
-producing cells may be an important
factor in triggering inflammation that is pathogenic and destructive
Author's Homepage:
http://people.tcd.ie/lynchmaDescription:
PUBLISHED
Author: LYNCH, MARINA
Type of material:
Journal ArticleCollections
Series/Report no:
Immunology141
3
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Full text availableDOI:
http://dx.doi.org/10.1111/imm.12156Metadata
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