Browsing Pharmacology & Therapeutics (Theses and Dissertations) by Title

Now showing items 41-46 of 46

    • Stress and long-term potentiation 

      Shakesby, Alison (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)
      Stress is a physiological reaction which the body copes with by a variety of mechanisms in order to restore homeostasis. Amongst these is an increase in plasma glucocorticoids, catecholamines and increases in brain ...

    • Structural remodelling of the vascular wall in relation to ageing and arterial stiffening 

      McNulty, Marie (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
      Structural remodelling of the vascular wall has been investigated in this study in terms of ageing and the process of vascular stiffening. While common structural adaptations are often presumed for ageing and vascular ...

    • Synaptic plasticity in animal models of stress : serotonergic mechanisms 

      Ryan, Benedict K. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)
      The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ...

    • The influence of antiviral therapy and HIV / HCV proteins on matrix metalloproteinase and cytokine production : an in vitro and in vivo study 

      Kennedy, Alan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)
      The effect of antiviral therapy on MMP/TIMP expression in THP-1 and LX-2 cells and in HIV/HCV co-infected patients: MMP-9 activity was measured by gelatin zymography, MMP-9 mRNA expression by real-time RT PCR, and MMP-9, ...

    • The use of the General Medical Services prescription database for pharmacoepidemiological studies in Ireland 

      Williams, David (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)
      Pharmacoepidemiology may be divided into three main subdivisions, namely pharmacovigilence, drug utilisation and prescribing quality. An aim of this thesis was to demonstrate the usefulness of the General Medical Services ...

    • β-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts 

      Rietz, Anne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)
      Adrenoceptor signalling in fibroblasts: Intracellular cAMP levels were measured by a direct cAMP enzyme immunoassay. Isoprenaline (ISO, 1 μM) increased intracellular cAMP concentration by 1.3 and 4.8 fold, P<0.05, after ...