Browsing Chemistry (Theses and Dissertations) by Title
Now showing items 355-374 of 395
-
The development of novel methodologies for the selective Tischenko reaction and the use of acylpyrazoles as directing groups in organocatalytic 1,4-conjugate addition reactions
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)Summary [end of chapter 1, page 59] Though significant advances in the field of organocatalytic Michael addition reactions have been achieved through the enantioselective additions of pronucleophiles to, in the main, ... -
The development of novel organocatalysts for asymmetric methylene transfer in the Corey-Chaykovsky reaction
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)To date, the enantioselective preparation of terminal three-membered heterocycles via the Corey-Chaykovsky (CC) reaction has been characterised by unsatisfactory enantioselectivities. In the benchmark literature report ... -
The electroanalytical applications of carbon nanotube-modified electrodes
(Trinity College (Dublin, Ireland). School of Chemistry, 2008)In this study, cyclic voltammetry, potential step chronoamperometry, batch amperometry, hydrodynamic voltammetry and electrochemical impedance spectroscopy were used to investigate the physical and chemical properties of ... -
The electromechanical properties of individual nanowires
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)The measurement of the mechanical and electrical properties of individual nanowires and nanowire systems is of paramount importance for their future incorporation into functional devices. An equally important property that ... -
The electronic structure of transparent conducting oxides
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Transparent conducting oxides (TCOs) are a unique class of materials which combine the normally mutually exclusive properties of transparency and conduction. Although their discovery dates back over a century and despite ... -
The evaluation of Carbotrap-B and Carbosieve SIII for volatile organic compounds sampling applications that use thermal desorption-gas chromatography as the analytical technique
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The effects of concentration, temperature and humidity on the value of breakthrough volumes (Vb) for forty-four volatile organic compounds (VOC) on Carbotrap-B have been determined using the frontal chromatography method. ... -
The immobilisation of TiO2 in various heterogeneous hosts for the photocatalytic oxidation of cyanide
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)The main focus of this study lies in the preparation and characterisation of TiO2. The formation of a nanoparticulate semiconductor may offer interesting photophysical properties and have applications as a photocatalyst. ... -
The origin of structural distortions in metal ceramics
(Trinity College (Dublin, Ireland). School of Chemistry, 2006)Ceramics containing Pb, Sn, Bi, Hg and T1 metals represent a class of materials with numerous technologically relevant current and potential applications. Despite the large quantity of experimental and theoretical efforts ... -
The rational design and synthesis of novel a-2 andrenoceptor antagonists as potential antidepressants
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Depression is one of the leading causes of illness worldwide and has been closely linked to low concentrations of monoaminergic neurotransmitters in the brain. Activation of presynaptic alpha-2 adrenoceptors (a2-AR) by the ... -
The self-assembly of polynuclear transition mental complexes, metallo-helicates and extended coordination assemblies
(Trinity College (Dublin, Ireland). School of Chemistry, 2012) -
The synthesis and biological evaluation of Mycobacterium tuberculosis associated glycan derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)Mycobacterium tuberculosis establishes chronic infection and causes disease through manipulation of the host's innate and adaptive immune response. The bacterial cell wall is highly complex and contains a rich variety of ... -
The synthesis and chemistry of macrolactones
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)The work herein presented is an investigation into the methodology of macrolactonisation via an intramolecular acylative cleavage of a tetrahydrofuran ring. The thesis is divided into three Chapters: an introduction outlining ... -
The synthesis and photochemistry of some 3-phenylenones
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The excited triplet state of 3-phenylcyclohexenone has been studied by laser flash photolysis and time-resolved infrared spectroscopy. Laser flash photolysis has been used to determine rate constants of decay of excited ... -
The synthesis and testing of inhibitors for the enzyme GTP-cyclohydrolase (I)
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)This thesis investigates the design and synthesis of compounds to be tested as inhibitors of the enzyme guanosine triphosphate cyclohydrolase (I), an enzyme which plays an important role in the biosynthesis of almost all ... -
The synthesis of analogues of mecamylamine
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The anti-hypertensive drug MA (Inversine®) has been investigated for and shown antiaddictive and anti-depressive properties, in both human subjects and animal models. Due to its restrictive synthesis, structure-activity ... -
The synthesis of prodrugs derived from PaTrin-2
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)Chemotherapeutic alkylating agents, like triazenes and nitrosoureas, whose mechanism of action involves the modification of guanine residues at the 06 -position in DNA are often rendered ineffective by the repair enzyme ... -
The synthesis of steroidal-based anion receptors and analysis of their binding properties
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)Chapter one is an introduction to molecular recognition and supramolecular chemistry; their origin and the history of their progress in recent years. It includes a brief account of the factors that must be considered when ... -
The synthesis, characterisation and photophysical properties of novel tri-substituted-8-azafluoranthene compounds and their Cu(1) complexes
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Chapter 1: This chapter details the synthesis and charaeterisation of a family of novel tri-substituted-8-azafluoranthene eompounds that have N^N bidentate ligand capabilities. The compounds are synthesised via a Diels-Alder ... -
The synthesis, photophysical and biological evaluation of Novel Bis(1,8-naphthalimides)
(Trinity College (Dublin, Ireland). School of Chemistry, 2007)Chapter One provides a review of 1,8-naphthalimide research and, in particular, the exploration of such compounds as anti-cancer agents. Advances in anti-cancer therapeutics and targeting of DNA are also discussed. A ... -
The synthesis, spectroscopic and electrochemical investigation of thienyl derivatives of polyaromatic hydrocarbons
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)