The rational design and synthesis of novel a-2 andrenoceptor antagonists as potential antidepressants
Citation:
Daniel Hillebrand O'Donovan, 'The rational design and synthesis of novel a-2 andrenoceptor antagonists as potential antidepressants', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2011, pp 240Download Item:
Abstract:
Depression is one of the leading causes of illness worldwide and has been closely linked to low concentrations of monoaminergic neurotransmitters in the brain. Activation of presynaptic alpha-2 adrenoceptors (a2-AR) by the endogenous ligands noradrenaline (NA) and adrenaline (AD) results in a decrease in the release of monoaminergic neurotransmitters. Therefore, the administration of a2-AR antagonists leads to increased concentrations of brain monoamines and constitutes a viable strategy for the treatment for depression.
Author: O'Donovan, Daniel Hillebrand
Advisor:
Rozas, IsobelQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Chemistry, Ph.D., Ph.D. Trinity College Dublin.Metadata
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