The synthesis and chemistry of macrolactones
Citation:Lawrence D. Cook, 'The synthesis and chemistry of macrolactones', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2014, pp 315
Cook TCD THESIS 10545 The synthesis.pdf (PDF) 146.1Mb
The work herein presented is an investigation into the methodology of macrolactonisation via an intramolecular acylative cleavage of a tetrahydrofuran ring. The thesis is divided into three Chapters: an introduction outlining the history and biological role of macrolactones, and the techniques currently being exploited in their synthesis; an improvement upon the technique of macrolactonisation via intramolecular acylative cleavage of tetrahydrofuran rings; and progress towards the total synthesis of the naturally occurring macrolactone curvularin.
Author: Cook, Lawrence D.
Publisher:Trinity College (Dublin, Ireland). School of Chemistry
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Type of material:thesis
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