The SNP ratio test: pathway analysis of genome-wide association datasets
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2009Citation:
O'Dushlaine, C., Kenny, E., Heron, E.A., Segurado, R., Gill, M., Morris, D.W. & Corvin, A., The SNP ratio test: pathway analysis of genome-wide association datasets., Bioinformatics, 25, 20, 2009, 2762 - 2763Download Item:
The SNP ratio test.pdf (Published (publisher's copy) - Peer Reviewed) 118.9Kb
Abstract:
Summary: We present a tool that assesses the enrichment of
significant associations from genome-wide association studies
(GWAS) in a pathway context. The SNP ratio test (SRT) compares the
proportion of significant to all SNPs within genes that are part of a
pathway and computes an empirical P-value based on comparisons
to ratios in datasets where the assignment of case/control status
has been randomized. We applied the SRT to a Parkinson's disease
GWAS dataset, using the KEGG database, revealing significance for
Parkinson's disease and related pathways
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https://academic.oup.com/bioinformatics/article/25/20/2762/193100http://hdl.handle.net/2262/91817
Author's Homepage:
http://people.tcd.ie/eaheronhttp://people.tcd.ie/morrisdw
http://people.tcd.ie/acorvin
http://people.tcd.ie/mgill
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PUBLISHED
Author: MORRIS, DEREK; HERON, ELIZABETH ANN; CORVIN, AIDEN PETER; GILL, MICHAEL; O'Dushlaine, Colm; Kenny, Elaine; Segurado, Ricardo
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Journal ArticleURI:
https://academic.oup.com/bioinformatics/article/25/20/2762/193100http://hdl.handle.net/2262/91817
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Bioinformatics;25;
20;
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https://doi.org/10.1093/bioinformatics/btp448Licences:
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