| dc.contributor.author | MORRIS, DEREK | |
| dc.contributor.author | HERON, ELIZABETH ANN | |
| dc.contributor.author | CORVIN, AIDEN PETER | |
| dc.contributor.author | GILL, MICHAEL | |
| dc.contributor.author | O'Dushlaine, Colm | |
| dc.contributor.author | Kenny, Elaine | |
| dc.contributor.author | Segurado, Ricardo | |
| dc.date.accessioned | 2020-03-18T13:44:23Z | |
| dc.date.available | 2020-03-18T13:44:23Z | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009 | en |
| dc.identifier.citation | O'Dushlaine, C., Kenny, E., Heron, E.A., Segurado, R., Gill, M., Morris, D.W. & Corvin, A., The SNP ratio test: pathway analysis of genome-wide association datasets., Bioinformatics, 25, 20, 2009, 2762 - 2763 | en |
| dc.identifier.other | Y | |
| dc.identifier.uri | https://academic.oup.com/bioinformatics/article/25/20/2762/193100 | |
| dc.identifier.uri | http://hdl.handle.net/2262/91817 | |
| dc.description | PUBLISHED | en |
| dc.description.abstract | Summary: We present a tool that assesses the enrichment of
significant associations from genome-wide association studies
(GWAS) in a pathway context. The SNP ratio test (SRT) compares the
proportion of significant to all SNPs within genes that are part of a
pathway and computes an empirical P-value based on comparisons
to ratios in datasets where the assignment of case/control status
has been randomized. We applied the SRT to a Parkinson's disease
GWAS dataset, using the KEGG database, revealing significance for
Parkinson's disease and related pathways | en |
| dc.description.sponsorship | Health Research Board of Ireland (HRB), Irish Research
Council for Science, Engineering and Technology (IRCSET) and
Science Foundation Ireland (SFI). | en |
| dc.format.extent | 2762 | en |
| dc.format.extent | 2763 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Bioinformatics; | |
| dc.relation.ispartofseries | 25; | |
| dc.relation.ispartofseries | 20; | |
| dc.rights | Y | en |
| dc.subject | GWAS dataset | en |
| dc.subject | Genome-wide association studies | en |
| dc.subject | Parkinson's disease | en |
| dc.title | The SNP ratio test: pathway analysis of genome-wide association datasets | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/eaheron | |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/morrisdw | |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/acorvin | |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/mgill | |
| dc.identifier.rssinternalid | 62039 | |
| dc.identifier.doi | https://doi.org/10.1093/bioinformatics/btp448 | |
