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Recent Submissions
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Antimicrobial susceptibility, resistance determinants and molecular epidemiology of Neisseria gonorrhoeae in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)High-level resistance to and treatment failures with ceftriaxone and azithromycin, the first line agents for treatment of gonorrhoea are reported and antimicrobial-resistant N. gonorrhoeae is now an urgent public health ... -
The role of GPR55 in neuronal and immune cell signalling and function
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)The orphan G-protein coupled receptor, GPR55, is widely expressed throughout the body and is responsive to cannabinoids. However, its endogenous ligand is believed to be L-a-lysophosphatidylinositol (LPI). GPR55 is expressed ... -
Association of PP2A and VE-cadherin in a mono and co-culture with implications on brain microvascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Introduction: Based on the knowledge that VE-cadherin is an integral component of the functioning endothelium in the blood brain barrier. Its transcellular abundance can be altered by post-translational modifications and ... -
Postprandial Cardiometabolic risk in Autoimmune Thyroid Disease and Type 1 Diabetes Mellitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Atherosclerosis is implicated in the development of CVD. Postprandial lipaemia is independently predictive of atherogenesis and of ... -
The Pharmacokinetic Interaction between Ivacaftor and Ritonavir
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Ivacaftor is the first small molecule for the treatment of cystic fibrosis (CF) that directly targets the inherited defect in the cystic fibrosis transmembrane conductance regulator (CFTR). In phase III clinical trials ...
