Browsing by Author "HERON, ELIZABETH ANN"

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  • Exploration of empirical Bayes hierarchical modeling for the analysis of genome-wide association study data. 

    GILL, MICHAEL; HERON, ELIZABETH ANN; GALLAGHER, LOUISE (2011)
    In the analysis of genome-wide association (GWA) data, the aim is to detect statistical associations between single nucleotide polymorphisms (SNPs) and the disease or trait of interest. These SNPs, or the particular regions ...

  • A genomewide scan for common alleles affecting risk for autism. 

    SEGURADO, RICARDO; ANNEY, RICHARD JAMES LEON; MC GRATH, JANE; BOLSHAKOVA, NADEZDA; GILL, MICHAEL; HERON, ELIZABETH ANN; TANSEY, KATHERINE; GALLAGHER, LOUISE (Oxford University Press, 2010)
    Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ...

  • The SNP ratio test: pathway analysis of genome-wide association datasets 

    MORRIS, DEREK; HERON, ELIZABETH ANN; CORVIN, AIDEN PETER; GILL, MICHAEL; O'Dushlaine, Colm; Kenny, Elaine; Segurado, Ricardo (2009)
    Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to ...