Evolution of the OmpR regulon in Salmonella enterica serovar Typhimurium and Escherichia coli in response to low pH
Citation:
Heather J. Quinn, 'Evolution of the OmpR regulon in Salmonella enterica serovar Typhimurium and Escherichia coli in response to low pH', [thesis], Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013, pp 330Download Item:
Abstract:
Two-component systems (TCS) enable bacteria to sense, respond and adapt to a wide
range of environmental stimuli. The OmpR/EnvZ TCS is composed of the inner
membrane sensor kinase EnvZ and the response regulator OmpR. In Escherichia coli
(E. coli) EnvZ is stimulated by changes in osmotic pressure; EnvZ phosphorylates the
transcription factor OmpR, which differentially expresses the outer membrane porins
ompF and ompC. Comparatively, the orthologous OmpR/EnvZ TCS in Salmonella
enterica serovar Typhimurium (S. Typhimurium) does not respond to osmolarity.
Instead, studies have shown the ompR gene is activated by low pH and is essential for
the expression of pathogenicity genes. These findings raised the question does ompR in
E. coli respond to low pH?
Author: Quinn, Heather J.
Advisor:
Dorman, CharlesQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Genetics and MicrobiologyNote:
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