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Genetics (Theses and Dissertations)
Recent Submissions
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RNP granules-dependent translational regulation in habituation and development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Habituation is defined as a reduced behavioral response to a stimulus after repeated or continuous exposure. Long-term habituation (LTH) is a long-lasting form of non-associative memory which is dependent on de novo protein ... -
Understanding the role of Polycomb-like proteins in cellular quiescence and cancer
Polycomb proteins are a class of chromatin modifying complexes that are essential regulators of development, differentiation and maintenance of cell lineage. Polycomb proteins exist in two large, distinct, multimeric ... -
Genetic structure and trait estimation in ancient Europeans
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)The study of ancient human populations have mostly been carried out, until recently, by historians through the study of written records and ancient manufacts. Thanks to recent technological and theoretical advancements in ... -
Mechanisms of action and vulnerabilities associated with the oncogene EZH2 in germinal centre B-cell non-Hodgkin lymphoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb group (PcG) proteins are highly conserved chromatin regulators that play a critical role as transcriptional repressors in mediating and maintaining cellular identity. PcG proteins assemble into large, distinct, ... -
Genetic heterogeneity in amyotrophic lateral sclerosis and related disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The overarching aim of this thesis is to clarify and further our understanding of the genetic causes of amyotrophic lateral sclerosis (ALS) and related diseases. It is hoped that achieving this can help bring clarity to ...
