The role of the bile acid deoxycholate in gastrointestinal epithelial cell signalling
Citation:
Eileen Looby, 'The role of the bile acid deoxycholate in gastrointestinal epithelial cell signalling', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005, pp 252Download Item:
Looby TCD THESIS 7574 The role.pdf (PDF) 171.8Mb
Abstract:
Environmental and dietary factors are implicated in the aetiology of human cancer. Bile
acids, the amphiphilic derivatives of cholesterol, are strongly implicated in colonic and
oesophageal carcinogenesis. While bile acids themselves cannot induce tumours, they are
generally regarded as being tumour promoters. The exact mechanism of their tumour
promoting activity is uncertain but it is likely to involve alterations in epithelial cell
signalling cascades and gene expression systems. The ability of deoxycholic acid (DCA), a
potent bile acid, to modify intracellular signalling cascades such as protein kinase C (PKC)
and mitogen activated protein kinase (MAPK) was examined. As bile acids are also thought
to mediate their tumour promoting effects through transcriptional deregulation, DCAinduced
alterations in the transcription factor, activator protein-1 (AP-1), were investigated.
The findings of this thesis provide a further understanding of the role of DCA in
gastrointestinal tumour cell development through the persistent activation of MAPK and
AP-1 contributing to deregulated expression of downstream targets such as COX-2.
Author: Looby, Eileen
Advisor:
Kelleher, DermotQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
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